Award Data

DESCRIPTION provided by applicant Next Generation Sequencing NGS technologies provide a key mechanism in the expansion of precision medicine wherein treatments are designed based on the genetics unique to an individual patientandapos s illness A long standing and effective application of this concept has been in the clinical arena of hematopoietic cell transplants HCTs where for over ...

DESCRIPTION provided by applicant As the population continues to age degenerative ocular diseases become increasingly common and create tremendous burden on the health care system Vision impairment in the elderly with AMD takes away an average of quality years of life Age related macular degeneration AMD represents a large market with million patients and another million people at ...

DESCRIPTION provided by applicant Prostate cancer PCa is the most commonly diagnosed cancer and second leading cause of cancer death in American men The utility of the widely accepted diagnostic test for PCa the PSA test has come under severe scrutiny as only of men with PCa have levels that fall within the current PSA reference range Elevated PSA levels are not correlated well wit ...

DESCRIPTION provided by applicant Stress urinary incontinence SUI in women is an increase of pelvic floor compliance which results in decrease of urethral pressure typically through childbirth and presents as urine leakage during exertion SUI has significant impact on womenandapos s health including an association with increased levels of depression Curative options are limited to the in ...

DESCRIPTION provided by applicant Objective The goals of this Phase II SBIR proposal are to evaluate longer term patency and safety of a novel hemodialysis access graft design ePTFE treated with textured microporous silicone exterior layer and complete the necessary development steps to prepare the device for clinical evaluation The Phase I feasibility study demonstrated markedly superior p ...

DESCRIPTION provided by applicant Early detection of autism leads to earlier treatment which is proven to have a major impact on outcomes In spite of recent advances in early Autism Spectrum Disorders ASD detection the average age of diagnosis in the US is still around five ASD diagnosis is currently performed via behavioral assessment which requires highly specialized training is not w ...

DESCRIPTION provided by applicant Current practice in the USA for inoperable esophageal cancer is a palliative treatment using metal stent for end stage cancer patients Outside the USA especially in far east countries including China and Korea there have been reported clinical benefits of attaching sealed sources such as prostate seeds to the outside of an esophageal stent Although sim ...

DESCRIPTION provided by applicant We are developing the Indicator Cell Assay Platform iCAP a broadly applicable and inexpensive platform for blood based diagnostics that can be used for early detection of disease and as a companion diagnostic for drug development The iCAP uses cultured cells as biosensors capitalizing on the ability of cells to respond differently to signals present in th ...

DESCRIPTION provided by applicant Missing data censored data and surrogate markers are common incomplete data problems in biomedical data analysis In this project we are interested in statistical methods for experimental observational and genetic studies where there exist missing data measurement errors and surrogate markers Examples include health surveys containing non responders or m ...

DESCRIPTION provided by applicant This proposed Phase II project will lead to a commercial product capable of transfecting individual target cells This new biotool uses a patented microfabricated chip called a nanofountain probe NFP to deliver molecules into live individual target cells by single cell electroporation which induces temporary nanopores in the cell membrane via the applicat ...