Award Data

DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

DESCRIPTION provided by applicant Osteoarthritis OA diagnosed in over of the US population is the primary cause of musculoskeletal lower extremity disability Although there is no cure exercise remains the core treatment to manage OA regardless of age comorbidity pain severity or disability Yet many people with this condition do not engage in regular fitness and thus may resort t ...

DESCRIPTION provided by applicant This multi phase SBIR project targets a significant problem within the mission of the National Institute of General Medical Sciences rapid size based separation of small Da molecules in bio manufacturing The aim here is to simplify and radically improve this currently multi stage and a resource intensive process Manufacturing of active pharmaceut ...

DESCRIPTION provided by applicant The objective of this Phase I proposal is to demonstrate the feasibility of an innovative Cloud Information Management Bundle system CLIMBandquot that will increase efficiency and improve capabilities in animal model data management Current data management systems for animal model research have limitations For example paper based recording systems used by ...

DESCRIPTION provided by applicant We propose to evaluate the functionality MRI and bio compatibility of probes for microscopic magnetic stimulation mMS a new brain stimulation technology Moreover it has been demonstrated that the orientation of the applied MS fields relative to the excitable tissue provides unique activation of neuronal elements not seen with traditional electrical st ...

DESCRIPTION provided by applicant There are an estimated million Americans with chronic kidney disease CKD Early diagnosis and treatment are the only cost effective means to reverse this growing problem NIH recognizes the challenge to diagnose CKD early during its initiation and development phases in order to prevent further renal damage reduce cardiovascular risk and minimize the econ ...

DESCRIPTION (provided by applicant): Vaccination significantly reduces morbidity and mortality caused by annual influenza epidemics. Traditionally, influenza vaccines have been manufactured using adapted influenza virus grown in eggs. However, this methodsuffers from inherent disadvantages such as slow production and allergenic egg proteins in the final product. To avoid these drawbacks, new vacci ...

DESCRIPTION (provided by applicant): Coal-fired power plants and burners are vital drivers of the U.S. economy-but they unfortunately produce substantial amounts of mercury (Hg) that are seriously harmful to human health, particularly linked to damages ofthe nervous system. Healthcare costs due to Hg exposure are estimated to be in the billions of dollars annually. New mercury-emission regulations ...

Project Summary / Abstract Therapeutic proteins, or biologics, represent a 100 billion market that includes drugs such as antibodies, hormones, and many others. The clinical efficacy of biologics is critically determined by their circulating half-lives.Hence, various methods have been developed to increase their circulating half-lives by reducing clearance rates. This is commonly achieved by che ...