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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. CardioPort to Enable Intracardiac Beating Heart and Minimally Invasive Open Heart Surgery

    SBC: Nido Surgical, Inc            Topic: NHLBI

    DESCRIPTIONprovided by applicantThe goal of this Fast Track STTR project is to develop a novel CardioPortTM surgical device that will enable minimally invasive beating heart repair without use of cardiopulmonary bypassCPBThere is a critical unmet need for new instruments to improve the surgical repair of heart defects in childrenCurrent best surgical practices involve either open heart surgery wit ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Exploratory Chemistry on a new antibiotic

    SBC: NOVOBIOTIC PHARMACEUTICALS, LLC            Topic: NIAID

    This project studies the structure activity relationship SAR of the newly discovered antibiotic teixobactin with the goal of delivering a candidate that has development advantages over the parent compound Teixobactin is an unusual depsipeptide that is the first member of a novel class of peptidoglycan synthesis inhibitors Teixobactin targets lipid II peptidoglycan precursor and lipid III t ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Purging Latent HIV Reservoirs through a Combination HIV Therapeutic

    SBC: APHIOS CORPORATION            Topic: NIAID

    PROJECT SUMMARY We hypothesize that Protein Kinase C PKC agonists such as the non tumorigenic Bryoids combined with HDAC inhibitors HDACi represent a valuable pharmacological approach to purge latent HIV from cellular reservoirs We also hypothesize that a combination of a Bryoid and an HDACi co encapsulated in a long circulation pegylated immunonanosomes coated with anti PD L nanobodies w ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. High Speed Multi sensor Light Field Deconvolution Microscopy for Whole Brain Recording of Neuronal Activity

    SBC: Leaflabs, LLC            Topic: 101

    DESCRIPTION provided by applicant Recording all the neural activity in a D volume with millisecond timescale precision is a key goal of the BRAIN initiative Recently in a collaborative project with the Vaziri lab IMP Vienna we adapted the strategy of lightfield microscopy for D volumetric imaging of fluorescent neural calcium responses Prevedel This technology enables computatio ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Electronics and computational hardware for ultra-high channel count electrophysio

    SBC: Leaflabs, LLC            Topic: 101

    DESCRIPTION provided by applicant The advent of in vivo multielectrode recording has indicated the importance of recording from large populations of neurons As a result there is much interest in creating new kinds of in vivo multielectrode arrays including the polytrode new kinds of microfabricated electrode arrays and new kinds of ultradense D electrode array And yet innovation on the ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Fluorescence Lifetime Dynamics to Understand Brain Neural Activities and Behavior

    SBC: ChiSquare Bioimaging, LLC            Topic: 500

    DESCRIPTION provided by applicant The overall objective of the proposed project is to create a compact robust and easy to use device that is capable of sensitive and quantitative detection of fluorescence lifetime indicators of physiological and biochemical dynamics deep in the brain of a freely moving mouse In contrast to fluorescence intensity based methods fluorescence lifetime can delin ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Optopatch: high-throughput all-optical electrophysiology for neural recording

    SBC: Q-State Biosciences, Inc.            Topic: 102

    DESCRIPTION provided by applicant Optopatch high throughput all optical electrophysiology for neural recording The convergence of stem cell genomic and advanced imaging technologies provides unprecedented ability to study human neural physiology in health and disease Traditionally intractable diseases schizophrenia autism Alzheimerandapos s ALS and Parkinsonandapos s are being modeled ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Transitioning Electronic Support for Public Health (ESP) from Lab to Marketplace

    SBC: Commonwealth Informatics, Inc.            Topic: 400

    DESCRIPTION provided by applicant Accurate and complete disease surveillance is critical to enable public health authorities to detect and respond to disease outbreaks epidemics and even bioterrorism events While legally required of healthcare practitioners and practices most notifiable disease reporting is still done manually or through limited automated laboratory test result reporting ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Novel beta lactams as inhibitors of ebola virus infections

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Ebola virus EBOV is a member of the filovirus family that causes severe viral hemorrhagic fever VHF Although infrequent epidemics of EBOV can cause high mortality rates of up to the subsequent medical and social upheaval can be widespread and severe as seen in the recent outbreak in Western Africa which has already caused more than fatalities ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. T SS needle protein inhibitors for the treatment of P aeruginosa infection

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The inability to treat many Gram negative bacterial infections effectively with existing antibiotics is a major medical crisis Pseudomonas aeruginosa is a prime example of clinical isolates from critically ill patients are resistant to three or more drugs The overall goal of this project is to address the critical medical need by a novel approach of iden ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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