Award Data

The utility of continuously tracking vehicles in a battlefield has been demonstrated during the Gulf War and other recent conflicts. However, the ability to achieve reliable continuous tracking in many environments will require the use of FOPEN radar andefficient use of sensor resources. In this effort we extend current research to include heterogeneous terrain and apply this model to simulations. ...

DESCRIPTION: (Adapted from Applicant's Abstract) Malaria is a disease which affects more than 300 million people each year and is fatal for 1.5 million. The overall objective of this STTR Phase I project is to produce a cGMP malaria vaccine consisting of the 42 kDa C-terminal polypeptide of P. falciparum merozoite surface protein-1 (MSP1.42) to be formulated with ...

DESCRIPTION (Applicant's abstract): Psoriasis is a common, inflammatory disease of the skin characterized by hyper-proliferation of keratinocytes. A variety of antipsoriatic therapies are available, however, due to problems with side effects and variability in clinical response, intense clinical and commercial interest remains in the development of new treatments. Thiaz ...

DESCRIPTION (Verbatim from Applicant): We will develop biomimetic materials for repair and orthoplasty of the orbit and surrounding bony structures. These scaffolds will incorporate a cell binding peptide related to collagen which will allow them to serve as collagen-like anchorages for cells. These Collagen Surrogate Matrices (CSM) will facilitate haptotactic migrati ...

DESCRIPTION:(provided by applicant) The goal of this project is to develop a novel inhibitor of methane formation in ruminant animals. Currently, monensin, a relatively nonspecific antibiotic, is widely used in the livestock industry. Monensin increases agricultural productivity by decreasing methane and increasing propionate production; however, it also inhibits ...

DESCRIPTION: (Adapted from the Applicant's Abstract) Traumatic spinal cord injury (SCI) leads to permanent loss of motor function and control of function below the level of the injury. A significant portion of the loss is due to secondary factors rather than the initial trauma. These factors include increased extracellular concentrations of glutamate which ha ...

DESCRIPTION (provided by applicant): Cocaine abuse remains a grave concern for the American, and increasingly the world, population. As no current therapeutic agents are available to assist cocaine addicts in achieving and maintaining abstinence it is important that new pharmacotherapies be developed. One important question not usually addressed in the development ...

DESCRIPTION (provided by applicant): Identifying amino acid residues of a protein that form the binding site for a drug, or that are present at the interface in a protein-protein complex are difficult to identify from the crystal structures of the individual partner proteins. Carta Proteomics is committed to the premise that monitoring isotope exchange in ...

DESCRIPTION (provided by applicant): The most commonly used statistical methods for the design and analysis of cancer clinical trials today rely heavily on the idea of proportional hazards or its generalizations; i.e., that the important differences between treatments are reflected in the differences between failure rates. Implicit in the use of these methods is the assumptio ...

DESCRIPTION Adapted from applicant's abstract): Aging is accompanied by a slow decline in cognitive function, now referred to as mild cognitive impairment (MCI), and by accumulation of oxidized proteins and lipids as a result of oxidative stress. Eukarion has discovered a new class of manganese complexes that display both superoxide dismutase (SOD) and catalase ac ...