Award Data

DESCRIPTION provided by applicant In an effort to reduce the use of animals for toxicity testing companies have developed in vitro skin models or equivalents to replace the Draize skin irritation test This development has been further pushed by the European Union regulation that has prohibited the use of animals for collecting toxicological data on cosmetic ingredients that began Supply ...

DESCRIPTION provided by applicant Non small cell lung cancer NSCLC is the most common lung cancer Half of NSCLC shows WNT activation marking poor survival StemSynergy Therapeutics Inc SSTI has identified a family of WNT inhibitors based on a novel chemical scaffold with our lead molecule SST demonstrating efficacy against WNT driven colorectal cancer In Phase I SBIR studies many ...

DESCRIPTION provided by applicant Severe oxalate related conditions such as primary hyperoxaluria PH secondary hyperoxaluria SH as a result of short bowel syndrome chronic inflammatory bowel disease cystic fibrosis post bariatric and other malabsorption syndromes Zellweger spectrum disorders ZSD and chronic and end stage renal failure continues to be a healthcare problem without ...

DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

DESCRIPTION provided by applicant The corneal endothelium plays a pivotal role in maintaining corneal transparency Unlike in other species the human corneal endothelium is notorious for its limited proliferative capacity in vivo after diseases injury aging and surgery Persistent corneal endothelial dysfunction leads to sight threatening bullous keratopathy Presently the only solution to ...

DESCRIPTION provided by applicant Bladder cancer is the fifth most common cancer in the United States Over of patients initially present with non muscle invasive bladder cancer NMIBC confined to the mucosa of the bladder These patients are treated by tumor resection followed by intravesical chemotherapy or Bacillus Calmette Gu rin BCG therapy Despite treatment of NMIBC pat ...

DESCRIPTION provided by applicant Acute pesticide poisoning remains a vast health problem in the developed and developing world Domestically a study estimates that of every US agricultural workers suffer from acute pesticide poisoning On top of that long time effects have also been observed with an increased risk for lymphomas and prostate brain leukemia cervix and stomac ...

DESCRIPTION provided by applicant This study aims to develop an improved neonatal hearing screening device that will incorporate novel testing procedures combining simultaneous air and bone conduction testing so that mild hearing losses andlt dB nHL are better and consistently detected The proposed device will address the current need for a more sensitive hearing screening tool by stimul ...

DESCRIPTION provided by applicant This SBIR Phase I project will develop a novel mobile framework to measure left ventricular ejection fraction as a marker for systolic dysfunction using automated non invasive analysis of cardiac signals Heart disease is the leading cause of death for men and women accounting for more than one third of all U S deaths In total costs associated w ...

DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...