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SUMMARY ABSTRACT Fine needle aspirationFNAcytology is the standard technique for evaluating thyroid nodulesHemorrhaging is common during the procedurehoweverleading to an aspirate that is significantly diluted by bloodSubsequent slide preparations are often suboptimalresulting in nondiagnostic outcomes that necessitate additional testing or diagnostic surgeryIn factquality is so unpredictable that ...

DESCRIPTION provided by applicant Autosomal dominant polycystic kidney disease ADPKD is characterized by the presence of innumerous fluid filled cysts that progressively enlarge leading nephron loss and the progressive decline in renal function Aberrant proliferation of the cyst lining epithelial cells and the accumulation of fluid within the cysts du to Cl dependent fluid secretion are res ...

DESCRIPTION provided by applicant Malignant primary brain tumors represent the most frequent cause of cancer death in children and young adults and account for more deaths than cancer of the kidney or melanoma Glioblastoma GBM is uniformly lethal and current therapy is non specific and produces a median overall survival of andlt months In contrast immunotherapeutic approaches are exq ...

DESCRIPTION provided by applicant Medical drugs and devices are regulated by the U S Food and Drug Administration FDA based on data from multicenter clinical trials In U S spending on clinical trials was approximately $ billion Over the past decade the efficiency of clinical trials has been improved by electronic data capture EDC systems whose use has increased from to ...

DESCRIPTION provided by applicant Antibiotic resistance has been declared one of the three greatest threats to human health by the World Health Organization Infections caused by multi drug resistant MDR bacterial pathogens create substantial health and economic impacts on society due to the lack of effective therapeutic options created by the rapid acquisition of resistance and stagnant anti ...

DESCRIPTION provided by applicant Nearly half of all college students have a diagnosable mental health problem Blanco et al College counseling centers CCCs are faced with increasing demands for services from Universities students and parents to meet the treatment needs of their students Kay and Schwartz in the context of increasingly severe cases and declining resources ...

DESCRIPTION provided by applicant Diabetes mellitus is a metabolic disorder afflicting more than million Americans This disease manifests itself with abnormal blood glucose levels that lead to other significant health conditions including kidney failure nerve damage blindness heart attack and stroke For more than million diabetics using insulin to control hyperglycemia frequent moni ...

DESCRIPTION provided by applicant An epidemic of addiction to prescription pain medications now causes deaths due to overdose that outnumber automobile related deaths rising admissions to hospitals and disrupted lives for both the patient and family The White House Office of National Drug Control Policy ONDCP report Epidemic Responding to Americaandapos s Prescription Drug Abuse Crisis ...

DESCRIPTION provided by applicant In more than million people reported using prescription pain medications opioids non medically without a prescription and million people reported using prescription painkillers non medically for the first time In o people older than initiated illicit drug use via non medical use of prescription drugs Each year the prob ...

DESCRIPTION provided by applicant NMR is arguably the most powerful analytical technique for structure determination and function elucidation in molecules of all types but there are complex challenges for biological macromolecules Dynamic Nuclear Polarization DNP with Magic Angle Spinning MAS has recently demonstrated S N gains of up to two orders of magnitude at K the lower tempera ...