Award Data

DESCRIPTION (provided by applicant): Nitric oxide (NO) is a critical regulator of cardiovascular physiology, coordinating the activities of the endothelium, the vessel wall and circulating cells to optimize the flow of blood and oxygen to tissues. Increasing the bioavailability of NO should provide therapeutic benefit in the treatment of many diseases ascribed to insufficient NO bioavailability. A ...

DESCRIPTION (provided by applicant): The overall goal of this proposal is to establish a novel freezing device that will prevent cell damage associated with extracellular ice formation during cryopreservation of rodent sperm. Rodent sperm have an unusual morphology compared to other mammalian species, with an asymmetric, falciform head and a relatively very long principle piece. They are also extr ...

DESCRIPTION (provided by applicant): The overall goal of this project is to establish new and novel methods and materials that will improve the low temperature storage of mammalian embryonic stem cells (ESCs). Here we propose to work only with mouse (i.e. non-human) ESCs. This work will result in intellectual property for the production of devices and disposables (e.g., media). ESCs are important ...

DESCRIPTION (provided by applicant): Biobehavioral research in a range of basic and translational disciplines (particularly cognitive neuroscience, neuropsychology and experimental psychology) increasingly involves the integration of multiple devices for the collection of data, such as EEG, fMRI, eye-tracking and physiological measurements (galvanic skin response, EKG). Current state-of-the-art ex ...

DESCRIPTION (provided by applicant): Detection and quantification of proteins in various biological samples is one of the most important and most often utilized assays with applications in research, medical diagnosis, early disease detection and detection of biological threat agents. While many protein detection methodologies are available (ELISA being a gold standard of those), they each have som ...

DESCRIPTION (provided by applicant): The long term goal of this research is to develop an efficient method to authenticate rodent cell lines. Misidentification as well as inter- and intra-species cross contamination of cell lines is widespread and has a substantial negative impact on biomedical research. The use of short tandem repeat (STR) analysis has been shown to be an effective means of authe ...