Award Data

ABSTRACT: This Phase II STTR research proposal aims to demonstrate an antenna coupled phase modulator based on an Electro-optic (EO) polymer refilled slot photonic crystal waveguide (PCW) for operation in the Q band. The goal is to detect field strengths of 100uW/m^2 in an Intensity Modulation Direct Detection (IMDD) scheme using subwavelength antennas. The EO polymer is the SEO125 provided by Dr ...

ABSTRACT: Pulsed power systems are utilized in several application platforms ranging from fuel reforming to biomedical applications. While significant advances have been made in development of solid state technology based power systems, the need for faster pulse rates as well as higher voltage requirements have resulted in a need for developing novel pulse power sources capable of pulsing at freq ...

ABSTRACT: Kerberos and SwRI plan to develop and evaluate new monitoring and broadcasting methods in a laboratory environment in the context of expected current and future military RF operating environments. Our proposed solution, called Electromagnetic Spectrum Monitor & Broadcast System (EMBS), will create a low-cost, small packaged device that can emulate anticipated opposing force broadcastin ...

ABSTRACT: In this program, Omega Optics, Inc., in collaboration with the University of Michigan Ann Arbor and the University of Texas at Austin, proposes to develop integrated photonic devices by using a combination of high-rate R2R nanoimprint lithography (R2RNIL) and R2R ink-jet printing. Patterning of photonic devices with sub-wavelength (

DESCRIPTION (provided by applicant): The ultimate goal of this application is to develop a novel ex vivo purging method using myxoma virus (MYXV), a rabbit-specific poxvirus, to improve the clinical outcomes in treatment of multiple myeloma (MM). MM is aclonal plasma cell malignancy that has to date resisted essentially all therapeutic strategies. Currently, the standard of care for patients wit ...

DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

DESCRIPTION (provided by applicant): This project proposes to develop and evaluate a hand rehabilitation system for chronic hemiparetic stroke survivors that have lost their ability to full control their hand. Stroke is the leading cause of adult disability, and is the third leading cause of death in the United States. Stroke survivors often face a significant loss of functional motor control in ...

DESCRIPTION (provided by applicant): Recent studies of the applicants support the role of the endogenous gaseous biological mediator hydrogen sulfide (H2S) in colorectal cancer: selective upregulation of cystathionine-b-synthase (CBS) and the subsequent production of H2S in colonic cancer cells serves as a pro-survival factor by stimulating tumor cell bioenergetics, growth, proliferation, migratio ...

Project Summary Oral ulceration is one of the most commonly encountered oral diseases, with an estimated prevalence of 4% in the USA. Managing large or multiple ulcers that are caused by diseases of unknown etiology, such as erosive lichen planus or aphthous ulcers which affect 25% of the population worldwide, is also a challenge to dentists and specialists. Ulceration of the oral mucosa can caus ...

DESCRIPTION (provided by applicant): Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. There is a clear need for more effective therapies to treat deadly pancreatic cancer disease. MicroRNAs (miRNA or miR) are a large group of short, noncoding RNAs that control posttranscriptional gene expression in human cells, and there is increasing evidence for the exi ...