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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Validation of Novel Therapeutic Approach for Cryptococcal Meningitis

    SBC: Minnetronix Medical, Inc.            Topic: NIAID

    Validation of a Novel Therapeutic Approach for Cryptococcal Meningitis PILadShivanand and McCabeAaron Project Summary When Cryptococcus is manifested as cryptococcal meningitisCMit creates a large burden of mortality and morbidity to the patient and is very difficult for the clinician to treatThere are now an estimatedUS cases andcases of CM worldwide annuallywith estimated mortality ofper yearCM ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Polo box PLK Inhibitors Target Tumors Resistant to ATP Competitive Compounds

    SBC: PPI PHARMACEUTICALS, LLC            Topic: NCI

    Polo like kinase PLK is a central player in regulating entry into and progression through mitosis Many studies have validated PLK as an anti tumor drug target and its inhibition is potently anti proliferative to cancer cells However recent data suggests that there are two major disadvantages of the conventional approach to blocking the kinase activity of PLK First both general kinome ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Scaffold to Promote Skin Regeneration

    SBC: FirstString Research, Inc            Topic: NIAMS

    PROJECT SUMMARY Dermal scarring affects more than million people worldwide annually over million people are injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction which leads to hypertrophic scar contractures HSc HSc a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Self crosslinkable hydrogel as an embolic agent for traumatic hemorrhage control

    SBC: Embomedics, Inc.            Topic: 300

    ABSTRACT Trauma is the th leading cause of morbidity and mortality after heart disease malignancies and lower respiratory illnesses in the United States Blunt abdominal trauma BAT is commonly caused by vehicular accidents and falls Uncontrolled bleeding is a major factor in early mortality after trauma contributing to to of trauma related deaths Transcatheter arterial embolization ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Monitored Breathing Awareness Therapy for Insomnia Disorder in Older Adults

    SBC: ADVANCED MEDICAL ELECTRONICS CORPORATION            Topic: NIA

    Insomnia of sufficient clinical severity to meet diagnostic criteria is present in approximatelyof older adultsnearlymillion individuals in the US aloneIf left untreatedit can lead to increased rates of depressioncognitive impairmentand cardiovascular diseaseTreatment relies on pharmacotherapysuch as sedativehypnotic therapywhich is associated with an increased risk of fallsaccidentsand deliriumco ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Using Technology to Optimize Child Mental Health Care In Real World Settings

    SBC: Minnesota HealthSolutions Corporation            Topic: 104

    Minnesota HealthSolutions MHS in conjunction with Mayo Clinic of Rochester proposes the current project to address the NIMH DSIR priority to develop novel tools for the dissemination and implementation of evidence based treatment EBT We propose to develop a web and mobile based platform eChildPsych which integrates assessment treatment tools progress monitoring and reporting This susta ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. The Restful Jaw Device A New Way to Support and Protect the Jaw During Third Molar Extractions

    SBC: RESTFUL JAW COMPANY, LLC, THE            Topic: NIDCR

    Project Summary Dental procedures can cause jaw pain and discomfort from opening too long too wide or from having too much downward force placed on the patientandapos s jaw These painful symptoms can be short lived or become chronic leading to temporomandibular muscle and joint disorders TMJD Third molar extractions wisdom teeth have been associated with a incidence of post operative TM ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Vastly improved influenza diagnostics through the development of a handheld thermal contrast reader

    SBC: Vigilant Diagnostics LLC            Topic: 600

    VIGILANT DIAGNOSTICS NIAID NIH STTR Phase I Application Vastly improved influenza diagnostics through the development of a portable thermal contrast reader PROJECT SUMMARY ABSTRACT Despite recent advances in rapid influenza diagnostic tests false negatives stemming from poor sensitivity contribute to nosocomial transmission and prevent thousands from receiving appropriate antiviral treatment A ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Non-ATP competitive inhibitors of cyclin dependent kinases as cancer therapeutics

    SBC: PPI PHARMACEUTICALS, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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