Award Data

DESCRIPTION provided by applicant Multiple sclerosis MS is a chronic demyelinating inflammatory disease that is the most common neurological disease of young adults affecting over patients in the US and over million patients worldwide MS is a disease of high unmet medical need currently treatable with one of twelve FDA approved drugs all of which result in either significant i ...

EpiZode: Noninvasive Seizure Screening in Preclinical Models of Epilepsy There is an urgent need for research into treatment options for epilepsy and other seizure disorders. Animal models are increasingly used to understand disease mechanisms and to screen promising therapeutic approaches. Animal epilepsy model use typically requires expensive and labor-intensive experimentation, with invasive EE ...

DESCRIPTION provided by applicant Bipolar disorder BD is a complex chronic illness characterized by recurrent often dramatic mood changes Self management of BD is an important component of treatment but is likewise complex and can be fraught with difficulties including misunderstanding of the condition and a lack of self awareness Combined with the nationwide shortage of mental healthcare ...

Project Summary Prostate cancer is one of the most commonly occurring forms of cancer, accounting for 21% of all cancer in men. The Prostate Imaging Reporting and Data System (PI-RADS) aims to standardize reporting of prostate cancer using multi-parametric magnetic resonance imaging (mpMRI). However, the in-depth analysis, as demanded by PI-RADS, remains challenging due to the complexity and heter ...

The future success of military teams operating in dynamic and uncertain environments will require the incorporation of artificial intelligence (AI) to help structure those teams, create plans of actions, execute those plans, and adapt plans as the environment and goals change. Successfully combining human of AI team members can achieve better results than either could on their own, but an uninform ...

Boston Fusion Corp. and Arizona State University will research and develop REsilience & Stability in DENse Terrains (RESIDENT), a multi-modal, multi-model, multi-scale framework for assessing indicators of stability and resilience in dense urban environments. Our team consists of subject matter experts in the Social and Computer Sciences providing the bedrock on which to build accurate mathematica ...

Stottler Henke proposes PACT to address the threat posed by unknown/novel bacteria. Stottler Henke’s solution leverages AI/ML technologies to assess the pathogenic potential of unknown/novel bacteria for DARPA’s Biological Technologies Office. Threat assessment is inferred from phenotype as characterized by a series of assays developed by Harvard University as part of DARPA’s Friend or Foe p ...

DESCRIPTION provided by applicant We propose to further develop field test and commercialize a reliable and robust sensor technology that allows the objective assessment of daily physical activity risk of falling frailty and activity organization among older adults in he home and community This is a Phase IIB STTR application During Phases Iandamp II BioSensics LLC in collaboration wit ...

Project Summary Normal human neuroanatomy is incredibly variable, and increases with age. This impedes the ability of neuroimaging to detect effects in neurological conditions such as Alzheimerandapos;s disease (AD), Huntingtonandapos;s disease (HD), multiple sclerosis (MS) and schizophrenia. Most of the recently available state-of-the-art quantitative imaging tools still use cross-sectional metho ...

DESCRIPTION provided by applicant The goal of this Phase II project is to optimize and validate a microfluidic chip based process that automates and shortens the labeling washing and collecting of human blood leukocytes WBCs for flow cytometric analysis of clinically important cell surface and intracellular markers Multi parameter flow cytometry is an increasingly powerful and widely used t ...