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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Mycotoxin Neutralization Treatment

    SBC: Physical Optics Corporation            Topic: CBD152003

    To address the Chemical and Biological Defense programs (CBDs) need for medical countermeasures against mycotoxin intoxication, PhysicalOptics Corporation (POC) proposes to develop a new Mycotoxin Neutralization Treatment (MyNT). This proposed solution is based on neutralizingmycotoxin from its deleterious effects by acting on multiple levels of mycotoxin metabolism through the novel combination o ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  2. Human monoclonal antibodies as countermeasures for T-2 mycotoxin

    SBC: Abzyme Therapeutics, LLC            Topic: CBD152003

    Mycotoxins are fungal toxins to which exposure frequently results in incapacitation or even in death. Natural outbreaks of mycotoxin poisoningare common worldwide. Due to its physical-chemical properties, high toxicity and relative ease to produce, mycotoxin T-2 is classified as apotential biological warfare agent. Currently there are no FDA approved medical countermeasures available for T-2 mycot ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  3. Mycotoxin Adsorption with Hemocompatible Porous Polymer Beads

    SBC: CytoSorbents Medical Inc.            Topic: CBD152003

    Acute exposure to mycotoxins can lead to systemic toxicity and even death. With no specific treatment available, aflatoxin and trichothecene T-2toxin, in particular, are of concern as potential biological weapons due to their toxicity, thermal and UV stability and easy accessibility. As amedical countermeasure, we propose the development of highly porous polymer beads optimized for removal of afla ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  4. Exploiting Natural Products-Based Therapeutics for Aflatoxin Mitigation

    SBC: CFD Research Corporation            Topic: CBD152003

    Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  5. Plasmid-seeded aligned nanofibrillar scaffold for acute muscle injury treatment

    SBC: Fibralign Corporation            Topic: DHP14009

    Based on encouraging Phase I feasibility results, we propose developing a novel gene therapy approach to promote guided vascular regeneration in treating extremities after traumatic injury. Our approach is to provide thread-like implants comprised of aligned nanofibrillar collagen scaffolds loaded with Hepatocyte Growth Factor (HGF) vectors (e.g., HGF DNA plasmid, modified mRNA) designed to enhanc ...

    SBIR Phase II 2016 Department of DefenseDefense Health Agency
  6. Use of Highly Porous Polymer Beads to Remove Anti-A and Anti-B Antibodies from Plasma for Transfusion

    SBC: CytoSorbents Medical Inc.            Topic: DHP15B001

    The ready availability of universal donor plasma to rapidly treat massively bleeding hospital trauma patients and warfighters with combat casualties is a key element of current recommendations for trauma resuscitation, yet universal AB donor plasma is rel

    SBIR Phase I 2016 Department of DefenseDefense Health Agency
  7. Smart Femtosecond Fiber Laser Wound Healing System

    SBC: POLARONYX, INC.            Topic: DHP15B002

    Based on our success in developing the world first commercial high energy femtosecond fiber laser system and our leading proprietary technology development in ultrashort pulsed fiber laser material processing, PolarOnyx proposes, for the first time, a compact high energy fiber laser based smart wound healing tool to meet with the requirement of this DHP solicitation. It includes a high energy fs f ...

    SBIR Phase I 2016 Department of DefenseDefense Health Agency
  8. High Fidelity Computational Models for Aggregated Tissue Interaction in Surgical Simulations

    SBC: CFD Research Corporation            Topic: DHP16A001

    Surgical simulations aiming to support surgeon practices and medical education have attracted enormous research effort over the last two decades. However, the physical reality, especially on simulating aggregated tissue interaction, is still unsatisfactory. In this proposed work, an open source surgery simulation framework, SoFMIS, will be utilized and enhanced with tissue interaction models to a ...

    STTR Phase I 2016 Department of DefenseDefense Health Agency
  9. Bio-mathematical Models of Aggregated Tissues & Organ Properties

    SBC: Corvid Innovation LLC            Topic: DHP16A001

    Realistic surgical simulation requires a combination of representative tissue geometry, accurate tissue material properties and lifelike tool-tissue interaction forces. Recent advances in computational power and imaging modalities have provided the capability to represent the anatomical details required for surgical training; however, the mathematical models which govern the underlying tissue pro ...

    STTR Phase I 2016 Department of DefenseDefense Health Agency
  10. Bio-Mathematical Models of Aggregated Tissues & Organ Properties

    SBC: BioMojo, LLC            Topic: DHP16A001

    BioMojo LLC and the Departments of Mathematics and Biomedical Engineering at the University of North Carolina Chapel Hill, will develop a preliminary bio mathematical model framework to represent how human tissues interact and behave at their boundaries. Tissue interaction properties (e.g. tensile, shear, friction, and so forth) of connective, epithelial, muscular, and nervous tissue including su ...

    STTR Phase I 2016 Department of DefenseDefense Health Agency
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