Award Data

DESCRIPTION provided by applicant Bipolar disorder BD is a complex chronic illness characterized by recurrent often dramatic mood changes Self management of BD is an important component of treatment but is likewise complex and can be fraught with difficulties including misunderstanding of the condition and a lack of self awareness Combined with the nationwide shortage of mental healthcare ...

ABSTRACT Obstructive sleep apnea OSA is the most common type of sleep apnea OSA affects an estimated million adults and of all children in the US OSA results in tiredness depression and fatigue and has several associated common comorbidities It is believed that over of OSA remains undiagnosed The prevalence of OSA increases with age and if untreated increases the risk of ...

DESCRIPTION provided by applicant The goal of this Phase II project is to optimize and validate a microfluidic chip based process that automates and shortens the labeling washing and collecting of human blood leukocytes WBCs for flow cytometric analysis of clinically important cell surface and intracellular markers Multi parameter flow cytometry is an increasingly powerful and widely used t ...

DESCRIPTION provided by applicant There is growing awareness that weakness of muscle is a significant biomedical health issue associated with many different chronic diseases and aging There are a variety of different diseases that affect muscle including muscular dystrophy fibromyalgia cerebral palsy amyotrophic lateral sclerosis and myasthenia gravis each of which carries its own uniqu ...

Control of extremely lightweight, long endurance aircraft poses a challenging aeroservoelastic (ASE) problem due to significantly increased flexibility, and aerodynamic, structural, and actuator nonlinearities. To obtain the benefits of increased aerostructural efficiency, the controller needs to trim at a specified optimal shape while minimizing structural fatigue from gust disturbances. Tao Syst ...

NanoSonic has developed revolutionary multifunctional, super lightweight, self-healing and radiation shielding carbon fiber reinforced polymer (CFRP) composites as a viable lightweight material for space applications such as primary or secondary structures on NASA vehicles, habitat modules, and pressure vessel structures. While current composites are lightweight, they do not offer reliable method ...

GTL has been developing a suite of transformational technologies that have the capability to disrupt the traditional launch vehicle paradigm. BHL composite cryotank technology provides a four times improvement over large aluminum iso-grid tanks, offering a 6 percentage point improvement in small stage PMF. Superior Stability Engine is an innovative liquid rocket engine configured to maximize comb ...

The technical objectives of this program are: (1) to develop a set of physics-based modeling tools to predict the initiation of hot corrosion and to address pit and fatigue crack formation in Ni-based alloys subjected to corrosive environments, (2) to implement this set of physics-based modeling tools into the DARWIN probabilistic life-prediction code, and (3) to demonstrate corrosion fatigue crac ...

Prime Photonics proposes to team with Dr. Duke of Virginia Tech to develop a multi-mode, enhanced piezoelectric acoustic emission sensing system to couple large damage events to local distribution of damage accommodation. Our system will be centered around an instrument designed to accept the output of a piezoelectric transducer sensitive to in-plane acoustic events. The signal processing path w ...

DESCRIPTION provided by applicant The goal of this STTR is to identify novel small molecule compounds targeting the nitrogen respiration pathway of Pseudomonas aeruginosa This pathway is crucial to the pathogenesis of P aeruginosa in vivo but has not yet been exploited for antimicrobial drug discovery There is a clear need for new treatments to combat P aeruginosa infections Antibiotic re ...