Award Data

The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust molecula

Establish a radiation-aware analysis capability in a commercial EDA design flow that will enable first-pass success in radiation-hardened by design (RHBD) for DoD ASICs in much the same way that existing EDA design suites ensure first pass functionality and performance success of complex ASICs destined for commercial applications. Layout-aware, calibrated single-event radiation models that captur ...

The broader impact/commercial potential of this project lies in development of a new class of amorphous metal alloys that could benefit society as a whole. Theoretical calculations have shown that 90% weight reduction of components can be achieved with Iron-based amorphous and nano-composite alloys. By reducing the weight of components in automotive and aerospace, significant fuel savings can be a ...

This Small Business Technology Transfer (STTR) Phase I Project aims to optimize and test prototypes of continuous, multi-analyte sensors based on stimuli-responsive hydrogels. The proposed sensor array will be capable of monitoring multiple biomarkers relevant to several common human diseases such as diabetes, ketoacidosis, chronic obstructive pulmonary disease (COPD) and even obesity. During this ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project will be to develop reliable technology for the production of aptamer pairs. Aptamers are core reagents in emerging markets, regarded as alternatives to monoclonal antibodies in therapeutics, diagnostics, and imaging. They possess several appealing qualities: Ease of in vitro synthesis, flexibl ...

The broader impact/commercial potential of this project is (1) the significant improvement in fertility rates among infertile couples and especially for patients suffering from non-obstructive azoospermia (NOA), which is found in 1% of the male population and in up to 20% of male infertility cases and is associated with non-measurable levels of sperm in the ejaculate. Automated systems to collect ...

The innovation proposed in this Small Business Innovation Research Phase II project will harness the popularity and ubiquity of mobile microgames on hand-held devices for educating children on self-management of chronic health conditions. Millions of children suffer from chronic conditions which require regular management, such as diabetes, or from broader states of poor health caused by obesity. ...

The broader impact/commercial potential of this project lies in its ability to implement multiple-input multiple-output (MIMO) detectors of any size. This, in turn, impacts the broad needs of wireless communications industry that is always in search of more efficient use of the scarce spectral resources. Since its invention 15 years ago, MIMO has been included in all wireless standards, e.g. WiFi, ...

This Small Business Technology Transfer (STTR) Phase I project proposes to improve intrinsic crop yield through metabolic engineering of photosynthetic pathways. Genes encoding five rate-limiting enzymes for photosynthesis and starch synthesis will be co-expressed constitutively or in a cell-specific manner in a model C4 plant species. Multiple metabolic pathways will be altered to simultaneously ...

The broader impacts of this Small Business Technology Transfer Phase I project relate to the increased viability of indigo as an agricultural crop competing with synthetically manufactured indigo dye. Indigo was among the major global cash crops of the 18th and 19th centuries and accounted for 100% of the indigo dye consumed in the world. Since the beginning of the 20th century, nearly 100% of the ...