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There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

On this effort Toyon Research Corp. and The Pennsylvania State University are developing deep learning-based algorithms for object recognition and new class discovery in look-down infrared (IR) imagery. Our approach involves the development of a hybrid classifier that exploits both transfer learning and semi-supervised paradigms in order to maintain good generalization accuracy, especially when li ...

"The next generation of very high field accelerator magnets (20 T or more) are expected to be made with high-temperature superconductors (HTS) along with conventional low-temperature superconductors (LTS) to reduce cost. The operation and protection of these magnets becomes very challenging particularly if the HTS coils are made with the tapes and operate at a much lower current than the LTS coils ...

To increase the utilization of electric vehicles, the US Department of Energy is seeking to reduce the cost of electric vehicle batteries to less than $125/kWh by 2022. To achieve this goal, the costs of cathode materials, which account for approximately 30% of the cost of vehicle batteries, must be reduced significantly. To address the challenge of lowering the costs of advanced lithium battery c ...

This Small Business Technology Transfer (STTR) program aims at development and demonstration of an integrated theoretically/experimentally combinatorial method for the accurate prediction of rheological behaviors of special polymer solutions. In-depth understandings of dynamic responses of the polymer solutions under external shear are essential for development of the “smart” polymer-based add ...

For effective protection against radiated threats, it is important to understand not only the physics of the threats, but also to quantify the effects they have on mission-critical electrical systems. Radiated vulnerability and susceptibility testing requires delivery of high peak power and peak electric fields to distant targets. The most practical solution to simulate such environments on large ...

The goal of this workis to establish a radiation-aware capability in a commercial EDA design flow that will enable first-pass success in radiation resiliency for DoD ASIC designs in much the same way that existing EDA design suites ensure first pass functionality and performance success of complex ASICs destined for commercial applications.Such an integrated capability does not presently exist.The ...

Sn-doped In2O3 (ITO) is the industry standard and most widely used transparent conducting electrode (TCE) because of its good electrical and optical properties. However, ITO has a number of disadvantages: ITO is not a suitable TCE for next-generation, high-efficiency, flexible OLEDs, because of its inappropriate work function, difficulty in creating desired patterns, low stability, delaminantion d ...