Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A High Throughput Screening Approach Enabling Sustainable Discovery of Novel Lead Compounds from Natural Product Extracts

    SBC: CFD Research Corporation            Topic: A07T034

    We propose the development of a high-throughput screening platform to facilitate the discovery of lead compounds from natural product extracts (NPEs). The proposed effort encompasses (a) utilization of NPEs from novel sources (cave organisms) with rich chemical diversity, (b) development of assays for specifically identified malaria targets, and (c) development of data management and analysis tool ...

    STTR Phase I 2007 Department of DefenseArmy
  2. A High Throughput Screening Approach Enabling Sustainable Discovery of Novel Lead Compounds from Natural Product Extracts

    SBC: CFD Research Corporation            Topic: A07T034

    Emerging drug resistance in infectious threats poses a health risk for deployed forces. The primary objective of the Phase I effort was to enable the development of a sustainable drug discovery effort to continually generate lead compounds for discovery and derivative synthesis. Successful completion of Phase I demonstrated the utilization of a novel source of lead compounds, validation of two hi ...

    STTR Phase II 2008 Department of DefenseArmy
  3. A Novel, Microscale, Distributable Sensor Technology for Ionizing Radiation

    SBC: CFD Research Corporation            Topic: DTRA14B004

    Terrorist use of radioactive nuclear materials via nuclear and/or radiological dispersion devices (dirty bombs) is a serious threat. Therefore, it is critical to detect the proliferation of nuclear material. Critical challenges facing this objective include: (a) high sensitivity detection of signature emissions (e.g., gamma rays) from common radioactive isotopes behind shielding, and (b) cost-effe ...

    STTR Phase I 2015 Department of DefenseDefense Threat Reduction Agency
  4. A Priori Error-Controlled Simulations of Electromagnetic Phenomena for HPC

    SBC: COMPUTATIONAL SCIENCES LLC            Topic: A11aT015

    The project will remove a key difficulty that currently hampers many existing methods for computing unsteady electromagnetic waves in unbounded regions. The accuracy and/or stability of the simulations may deteriorate over long times due to the treatment of the outer boundaries via artificial boundary conditions. We propose to develop a universal algorithm and software that will correct this probl ...

    STTR Phase I 2011 Department of DefenseArmy
  5. A Systems Biology Approach to Enable Safe Administration of Mefloquine

    SBC: CFD Research Corporation            Topic: A06T034

    The objective of this effort is to apply a systems-biology-centered methodology for the identification of subcellular mechanisms of mefloquine neurotoxicity, with the goal of developing a genetic profile to identify individuals predisposed to mefloquine neurotoxicity. The core hypothesis is that elucidating subcellular mechanisms of mefloquine neurotoxicity requires the combination of cellular lev ...

    STTR Phase I 2006 Department of DefenseArmy
  6. A Systems Biology Approach to Enable Safe Administration of Mefloquine

    SBC: CFD Research Corporation            Topic: A06T034

    Mefloquine is known to cause adverse neurological effects, possibly attributable to single nucleotide polymorphisms (SNPs). Our objective is to develop a genetic screen capable of determining the susceptibility of an individual to Mefloquine neurotoxicity. In Phase I, transcriptional profiling of primary neurons exposed to Mefloquine was used to construct an intracellular pathway model to explain ...

    STTR Phase II 2007 Department of DefenseArmy
  7. A universal framework for non-deteriorating time-domain numerical algorithms in Maxwell's electrodynamics

    SBC: COMPUTATIONAL SCIENCES LLC            Topic: A13AT008

    The project will remove a key difficulty that currently hampers many existing methods for computing unsteady electromagnetic waves on unbounded regions. Numerical accuracy and/or stability may deteriorate over long times due to the treatment of artificial outer boundaries. We propose to develop a universal algorithm and software that will correct this problem by employing the Huygens'principl ...

    STTR Phase I 2013 Department of DefenseArmy
  8. A universal framework for non-deteriorating time-domain numerical algorithms in Maxwell's electrodynamics

    SBC: COMPUTATIONAL SCIENCES LLC            Topic: A13AT008

    The project will remove a key difficulty that currently hampers many existing methods for computing unsteady electromagnetic waves on unbounded regions. Numerical accuracy and/or stability may deteriorate over long times due to the treatment of artificial outer boundaries. We propose to develop a universal algorithm and software that will correct this problem by employing the Huygens' principle an ...

    STTR Phase II 2014 Department of DefenseArmy
  9. An Automated, High Throughput, Filter-Free Pathogen Preconcentrator

    SBC: CFD Research Corporation            Topic: A10AT016

    Accurate real-time waterborne pathogen detection is of paramount importance to security of U.S. military forces and installations. Fieldable high-throughput pathogen concentration is a critical analytical need for enhanced detection performance. Existing concentration methods are time-consuming, bulky, labor-intensive, power- and reagent-hungry, and consequently ill-suited for battlefield deployme ...

    STTR Phase I 2010 Department of DefenseArmy
  10. An Ultra-Compact Low-Power THz Radio SoC with On-Chip Antenna and Energy Harvesting

    SBC: Digital Analog Integration, Inc.            Topic: A15AT005

    There is an unmet demand for ultra-low-power, ultra-compact and low-cost radios to address emerging sensing and communication needs for military and commercial applications such as IoT/IoE. To overcome the limitations in existing bulky and power hungry radios, we propose a disruptive solution by integration of a nano-scaled THz transceiver, on-chip antenna, and energy harvesting circuits in a form ...

    STTR Phase II 2016 Department of DefenseArmy
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