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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.
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Production of Inactivated Virus Vaccines Using Supralethal IrradiationSBC: BIOLOGICAL MIMETICS INC Topic: DTRA14B002
We seek a proof-of-concept study for the development of a new platform technology for the rapid and complete inactivation of pathogen infectivity for vaccine development of medically important micro-organisms (e.g. viruses, bacteria and parasites). A recently discovered reconstituted Mn+2-decapeptide phosphate complex (Mn-Dp-Pi) of the radiation-resistant bacterium Deinococcus radiodurans was foun ...STTR Phase I 2015 Department of DefenseDefense Threat Reduction Agency
A Novel, Microscale, Distributable Sensor Technology for Ionizing RadiationSBC: CFD RESEARCH CORPORATION Topic: DTRA14B004
Terrorist use of radioactive nuclear materials via nuclear and/or radiological dispersion devices (dirty bombs) is a serious threat. Therefore, it is critical to detect the proliferation of nuclear material. Critical challenges facing this objective include: (a) high sensitivity detection of signature emissions (e.g., gamma rays) from common radioactive isotopes behind shielding, and (b) cost-effe ...STTR Phase I 2015 Department of DefenseDefense Threat Reduction Agency
DOEYK: Detecting Objects with Enhanced YOLOv3 and Knowledge GraphSBC: Intelligent Automation, Inc. Topic: DTRA19B002
Current state-of-the-art object detection algorithms are almost exclusively based on Deep Convolutional Neural Network (DCNN). These algorithms all require a large amount of labeled examples for each of the object categories they can recognize. These algorithms will fail for novel objects that only very few or even no prior examples are available. These algorithms are also far less accurate when c ...STTR Phase I 2020 Department of DefenseDefense Threat Reduction Agency
Hardened, Optically-Based Temperature Characterization of Detonation EnvironmentsSBC: SA Photonics, Inc. Topic: DTRA19B001
Improving the effectiveness of counter-WMD operations requires improved understanding of weapon-target interaction. Specifically, time-resolved measurements of temperature and composition are required to allow temporal evolution of a detonation fireball. To address this need, SA Photonics will develop MONITOR, a laser-based temperature diagnostic that will enable wide dynamic range temperature mea ...STTR Phase I 2020 Department of DefenseDefense Threat Reduction Agency
Marburg Virus Prophylactic Medical CountermeasureSBC: Flow Pharma, Inc. Topic: CBD18A002
Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...STTR Phase II 2020 Department of DefenseOffice for Chemical and Biological Defense
Marburg Virus Prophylactic Medical CountermeasureSBC: MAPP BIOPHARMACEUTICAL, INC. Topic: CBD18A002
There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...STTR Phase II 2020 Department of DefenseOffice for Chemical and Biological Defense
Novel Circulating RNA-based Markers as Diagnostic Biomarkers of Infectious DiseasesSBC: CFD RESEARCH CORPORATION Topic: CBD18A001
In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens, whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial and alphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable an ...STTR Phase II 2020 Department of DefenseOffice for Chemical and Biological Defense