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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Broadband and Compact Dual Comb Spectrometer for Precise Field Detection of Trace Elements and Chemicals

    SBC: OPTICSLAH, LLC            Topic: DTRA20B003

    There is a growing need to accurately characterize nuclear materials not only for nuclear safeguards and nonproliferation treaty verification but also for forensics and provenance. Presently, nuclear material identification requires samples to be collected and sent to laboratories for analysis using large and expensive equipment, such as inductively coupled plasma mass spectrometers (ICP-MS) or se ...

    STTR Phase I 2021 Department of DefenseDefense Threat Reduction Agency
  2. Universal affinity membrane chromatography for rapid, one-step purification of proteins

    SBC: TriAltus Bioscience, LLC            Topic: 400

    Project Summary The goal of this STTR Phase I project is to demonstrate the feasibility of developing the first universal affinity membrane for the rapid, selective, one-step purification of difficult-to-purify proteins. Despite the urgency for expanding the application of gene editing systems and accelerating vaccine and antibody test development, the rapid purification of critical proteins such ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. Selective Androgen Receptor Degraders (SARDs) as new therapeutics for spinal and bulbar muscular atrophy (SBMA)

    SBC: ONCTERNAL THERAPEUTICS, INC.            Topic: NINDS

    PROJECT SUMMARY Kennedy’s disease also known as spinobulbar muscular atrophy (SBMA) is a progressive neurodegenerative disease caused by genetic polyglutamine expansion of the androgen receptor (AR). Recent research has shown that the mutant AR protein misfolds, aggregates, and abnormally interacts with other proteins, leading to hormone-dependent lower motor neuron degeneration and skeletal mus ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. High-density optical tomography of cerebral blood flow and metabolism in small animals

    SBC: BIOPTICS TECHNOLOGY LLC            Topic: 105

    ABSTRACT Many clinical situations, including stroke, expose the brain to insufficient cerebral blood flow (CBF) that cannot maintain normal cerebral metabolic rate of oxygen consumption (CMRO2) requirements, thereby leading to cerebral ischemic/hypoxic stresses and neurological disorders. Effective interventions are dependent on the findings of CBF/CMRO2 improvement and eventually neural recovery. ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Pulmonary Surface Irregularity score: A Quantitative CT Biomarker for Idiopathic Pulmonary Fibrosis

    SBC: AI METRICS, LLC            Topic: NIGMS

    PROJECT SUMMARY:Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic lung disease, with 50,000 new cases per year in the United States. IPF if a rapidly progressive and fatal disease, with half of patients dying within 2 years. The disease is heterogeneous, and there is wide variability in responsiveness to existing antifibrotic therapies. Development of new therapeutic agents for IPF a ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Developing a novel adjuvant system for therapeutic vaccines against lung cancer

    SBC: FasCure Therapeutics LLC            Topic: 102

    DESCRIPTION provided by applicant Therapeutics is focused on the development of adjuvant systems with desired immune activities for targeted indications The Companyandapos s immune stimulatory adjuvant platform builds on combinatorial use of immune agonists with distinct immune targets and mechanisms of action for the generation of therapeutic immune responses Critical to this platform techno ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. A cloud-based secure patient information exchange framework for managing treatment accessibility, utilization, quality, and outcomes in behavioral health clinics

    SBC: Waldron International llc            Topic: NIDA

    DESCRIPTION In communities across the United States clinical populations exhibiting mental health and or substance abuse disorders face substantial challenges in accessing and receiving high quality and effective behavioral healthcare services Health Information technology HIT has been identified as an important component of improving access to behavioral healthcare in rural communities yet t ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Clinical real-time resting state fMRI

    SBC: NeurInsight, LLC            Topic: 108

    DESCRIPTION provided by applicant Surgical resection of brain neoplasms aims at maximizing long term survival by gross total resection of tumor tissue while preserving the patientandapos s functional status Task based functional MRI fMRI is increasingly used as an adjunct to intra operative electrocorticography for mapping eloquent cortex but suffers a significant failure rate due to funct ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Target Identification for Novel Small Molecule Therapeutic for Alzheimer's disease

    SBC: CoPlex Therapeutics, LLC            Topic: NIA

    ABSTRACT Traditional approaches to drug development for Alzheimer s disease are becoming increasingly expensive and in many cases disappointingly unsuccessful Based on preliminary in vitro and in vivo studies we have identified a novel small molecule methyl dimethyl oxo dihydrobenzo c naphthyridine carboxylate UK that significantly decreases A production and pro in ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Mitochondrial TAT-DNA repair proteins for treatment of insulin resistance

    SBC: EXSCIEN CORPORATION            Topic: NIDDK

    DESCRIPTION provided by applicant Insulin resistance IR also known as metabolic syndrome is tied to obesity and is associated with numerous modern health problems including the growing problems of type diabetes and cardiovascular disease The growing health economic and social burdens of these conditions calls for the need to develop drug treatments for IR We know from multiple lines of ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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