Award Data

Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens, whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial and alphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable an ...

Traditional spherical optics implemented on a common optical axis are the foundation of today’s fielded gunsights for small arms fire control. SA Photonics has helped pioneer the application of precision injection molded freeform optical surfaces in head/helmet mounted display (HMD) systems for augmented reality (AR), virtual reality (VR) and low light level sensor applications. SA Photonics tea ...

In this SBIR project, a mathematical and numerical framework with efficient conforming methods for the design, analysis, and optimization of the performance of mobility system components will be developed. Phase I effort will focus on the development of automated isogeometric mesh generation to enable the dynamic simulations of surface deformation or relative motion encountered in applications suc ...

Advances in DNA sequencing technology have generated a rapid expansion of human genome information and the revelation of extraordinary individual-level genetic variation. Individual genome sequencing will soon be routine and cost-effective. To exploit this resource to the benefit of warfighters, we propose an approach for identifying and characterizing genetic variants that compromise metabolic ef ...

Epigenetic changes in DNA methylation pattern can result due to aging, diseases, or environmental changes and have been identified as biomarkers for several neuropsychiatric and neurodegenerative disorders, cancer, traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). As a result, DNA methylation signatures are being explored to assist with disease diagnosis, monitoring disease p ...

Next-level improvements in thermal extremity protection for the current Extended Cold Weather Clothing System (ECWCS) are needed for soldiers in order to improve mobility and achieve peak performance in bitterly cold Arctic climes. In this STTR program, 2W iTech LLC proposes to develop phase change material (PCM) based thermal regulating films, in collaboration with the Multiscale Thermal Science ...

The ALE-PNNL Team is developing a nonflammable high capacity and high power 18650 cell using nonflammable electrolyte for military electric vehicle and energy storage applications. The 18650 cells will be nonflammable even under extreme temperature conditions and after metal penetration, even including bullet penetration.

The US Army aims to integrate multi-modal sensor data streams and advanced AI analytics at the tactical network edge in support of its vision for a future Internet of Battlefield Things. To maintain situational awareness within mission-acceptable levels despite dynamic conditions and infrastructure disruptions, we propose the ConnextEdge framework for resource-aware location-agnostic adaptive AI p ...