Award Data

BaySpec Inc., in collaboration with Pacific Northwest National Laboratory, proposes to develop a new portable multi-order mass spectrometry system that can sequence peptides derived from biological agents including bacteria, viruses, and toxins. During Phase I stage, a fully functional prototype instrument, based on an innovative design concept, was successfully built and the performance evaluatio ...

PROJECT SUMMARY State of the art techniques result inyear solid organ graft loss ofto overin cardiopulmonary organ transplantationEstablishment of donor specific immunological toleranceDSITa condition in which a recipient accepts a transplant without immunosuppressionwhile retaining the ability to fight infectionswould reduce graft loss and transplant related complicationsThe only identified metho ...

PROJECT SUMMARY Assessment of loss of visual function outside the foveal area is an essential component of the management of numerous conditionsincluding glaucomaretinal and neurological disordersDespite the significant progress achieved with the development of standard automated perimetrySAPmany decades agoassessment of visual field loss with SAP still has significant drawbacksSAP testing is limi ...

PROJECT SUMMARY Chemotherapy induced peripheral neuropathyCIPNis a debilitating condition that afflictsof cancer patients undergoing chemotherapy and limits the dose and duration of treatmentSymptoms range from sensory loss to painful neuropathy and are accompanied by electrophysiological and structural indices of nerve damageThe American Society of Clinical Oncology currently makes no recommendat ...

ABSTRACT Osteoporosis is a major cause of disability and morbidity in our populationAs many asmillion Americans have osteoporosis andmillion more have osteopeniaHoweverbone mineral densityBMDassessment does not occur in many Americans when indicated and measure currently requires a separate referral and separate imaging scan to obtain BMDThe result is that onlyof Americans who are at risk of suffe ...

This STTR project will develop a wearable sensor suite for accurate assessment of circadian and sleep rhythms with the goal to identify abnormalities in PTSD patients and enable personalized therapy to help restore their normal functional and quality of life. Phase I has already demonstrated proof-of-principle hardware. The primary Phase II objective is to successfully carry out a human subjects s ...

The Tunable Active HEterodyne Terahertz Imager (TAHETI) system will use Terahertz Quantum-Cascade Lasers (QCL) combined with a Schottky diode detector for ultra-high dynamic range heterodyne imaging. Distributed feedback (DFB) QCLs with milliwatt power levels are engineered to emit at slightly offset frequencies, and are used as local oscillator and illumination for imaging. The QCLs will be down ...

Scanning probe microscopy (SPM) is a technique used to detect near-field interaction when a sample is rater-scanned by a probe. Example include atomic force microscope (AFM) and scanning tunneling microscope (STM). It offers nanometric and atomic image resolution. In this field, an emerging technique, Near-Field Scanning Microwave Microscopy (SMM), utilizes microwave evanescent waves to attain the ...

Integrated Solutions for Systems, Inc. (IS4S) and teammate Auburn University (AU) propose to develop a PNT initialization system for dismounted soldiers. The proposed system will enhance warfighters’ ability to operate immediately in a GPS denied environments once their mission begins and has wide commercialization potential outside of DoD. In Phase I, the feasibility and expected benefits of in ...

Our nation’s warfighters require advanced armor to give them the best protection while allowing mobility to perform their missions. This proposal will develop two powerful tools to aid future body armor advancements. First, this research program will develop a statistical analysis software that will predict likelihood of impacts based on defined attack scenarios (i.e. rifle, distance and firing ...