Award Data

DESCRIPTION (provided by applicant): This STTR proposal to the National Institute on Aging (NIA) requests funding to expand the capabilities of the Medicare Research Information Center (MedRIC) recently established by Acumen LLC with earlier support from NIA. The purpose of MedRIC is to facilitate the acquisition and linking of administrative data from the Centers for Medicare and Medicaid Service ...

DESCRIPTION (provided by applicant): This STTR proposal to the National Institute on Aging (NIA) requests funding to expand the capabilities of the Medicare Research Information Center (MedRIC) recently established by Acumen LLC with earlier support from NIA. The purpose of MedRIC is to facilitate the acquisition and linking of administrative data from the Centers for Medicare and Medicaid Service ...

DESCRIPTION (provided by applicant): 6. Project Summary-Abstract Modern societies face a mounting epidemic that cuts across all age groups: daily sleep loss. Cumulative sleep loss induces excessive daytime sleepiness and impairs cognitive performance. Among its many financial and physical consequences: sinking job productivity and rising auto accident rates. Clinicians increasingly note the negati ...

Not avaiable.

DESCRIPTION (provided by applicant): Cystic Fibrosis (CF) is an autosomal recessive disorder, which leads to the abnormal composition and physical properties of airway secretions in CF patients. Additionally, the lungs of CF patients are particularly susceptible to chronic bacterial infections with >80% of CF patients becoming chronically infected by 18 years of life with mucoid forms of Pseudomon ...

DESCRIPTION (provided by applicant): Human embryonic stem cells (HuES) have the potential to generate an unlimited source of beta/islet cells for transplantation, however the biologic factors required for this process have been difficult to ascertain partly due to the lack of stage specific in vitro cell assays. Recently, we have developed a murine in vitro pancreatic stem/progenitor colony assay ...

DESCRIPTION (provided by applicant): Mycobacterium tuberculosis and other Mycobacterium species are major pathogens around the world. They are part of a larger group of so-called fastidious pathogens that are difficult to study because, for a wide range of reasons, they are difficult to culture. Phenotype MicroArrayTM (PM) technology is a tool that can aid in understanding the physiological and me ...

DESCRIPTION (provided by applicant): Our long term goal is to develop a universal cell-based therapy containing human myeloid progenitor cells to attenuate radiation-induced gastrointestinal or hematopoietic injury. Radiation (XRT) remains an important therapeutic modality in the treatment of malignancies. Injury to the gastrointestinal tract (GI) and hematopoietic system are serious sequelae of r ...

DESCRIPTION (provided by applicant): Cerebral autoregulation that maintains perfusion in response to fluctuations of systemic blood pressure (BP) is lost post-stroke and traumatic brain injury (TBI). Noninvasive bedside methods are urgently needed to identify people with impaired autoregulation who may be at increased risk for stroke and adverse outcomes. The phase I goals are: 1) To develop and o ...

DESCRIPTION (provided by applicant): The overall goal of this Phase II project is to develop a novel R1-based method for MRI quantification of postinfarct myocardial viability using a commercially available contrast agent Gd(DTPA). The commercial embodiment of this method will be a software package that will convert a set of 2D cardiac MRI images to a 3D myocardial viability map, the Percent Infa ...