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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. AutoRegister: A system for enhancing the accuracy of tumor change detection

    SBC: CORTICOMETRICS LLC            Topic: 102

    PROJECT SUMMARY This project proposes to continue the development of AutoRegisterTMan integrated software based system for enhancing the accuracy of tumor change detectionThe intent of the system is to automate the alignment of a patient s brain scan with that of a prior scan such that subsequent offline tumor measurements do not have error introduced solely by differing slice orientationsWhile si ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development Characterization and Commercialization of a Viably Frozen Patient Inclusive Hepatocellular Carcinoma Tumor Bank

    SBC: Woodland Pharmaceuticals LLC            Topic: 103

    Abstract Hepatocellular carcinoma HCC is a disease of growing incidence globally including in the US by per year With the recent success of anti viral therapies the etiology of HCC in the American population is projected to shift from viral HBV HCV hepatitis to primarily fatty liver disease in the near future Currently only one effective systemic therapy has been developed for HCC ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. I- Corps Administrative Supplement to Novel Reagents for Breast Tumor SPECT Imaging R41CA217546

    SBC: Cavatar LLC            Topic: NCI

    PROJECT SUMMARY Early cancer detection and diagnosis are critical for patient survival and treatment successFor the imaging of breast and other solid tumorsthe diagnostic power of advanced imaging techniques such as SPECT could benefit tremendously from improved contrast agents that rapidly and selectively accumulate in tumor lesions and produce high tumor to background signal ratiosWe are develop ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of PAR Pepducins as a Novel Antithrombotic Treatment

    SBC: OASIS PHARMACEUTICALS, LLC            Topic: NHLBI

    Coronary artery disease remains the leading cause of death in the United States Platelets play an important role in the pathogenesis of acute coronary syndrome ACS as platelet activation aggregation and secretion are key components of arterial thrombus formation Despite dual anti platelet therapy for ACS and percutaneous coronary interventions PCI many patients sustain a high incidence u ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. UV emitting nanoparticles as novel radiation sensitizers targeting hypoxic cells

    SBC: Radiation Monitoring Devices, Inc.            Topic: 102

    Project Summary Abstract Radiation therapy is one of the primary therapeutic techniques for treating cancer Nearly two thirds of all cancer patients will receive radiation therapy during their illness with an average of radiation treatment episodes Although largely effective radiation therapy like other forms of cancer treatment has difficulty killing hypoxic regions within solid tumors ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Caveolae Targeted Cisplatin Immunoconjugates for Effective Lung Cancer Therapy

    SBC: Cavatar LLC            Topic: 102

    Abstract Caveolae at the endothelial cells surface can selectively rapidly and actively pump targeted antibodies out of the bloodstream and into underlying tissue in vivo even when they are conjugated to high molecular weight cargo Based on this exciting recent discovery we also found that caveolae pumping system enables unprecedented tumor specific targeting and penetration Taken together ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. My MESSAGE Improving Wayfinding and Reducing Challenging Behaviors in Persons with Dementia Through the Use of RFID Technology

    SBC: HEARTHSTONE ALZHEIMER CARE LTD.            Topic: NIA

    In the proposed study we will develop and evaluate a product called My MESSAGE Multimedia Ecopsychosocial Support System for Alzheimer s within Geriatric Environments which will circumvent the limitations of traditional visual cues and also provide unprecedented flexibility and precision for assisting with wayfinding and reducing other challenging behaviors in PWD The target consumer for MM w ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Quantitative Non Invasive Brain Imaging using Magnetic Nanoparticles

    SBC: TheraNano LLC            Topic: NIDA

    This Phase I STTR project is based upon a new technique Quantitative Ultra short Time to Echo Contrast Enhanced QUTE CE MRI utilizing UTE sequences with SuperParamagnetic Iron Oxide Nanoparticles SPION that leads to quantifiable vascular images with unprecedented clarity and definition QUTE CE is particularly optimal using Ferumoxytol an FDA approved iron oxide nanopharmaceutical The techni ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Alkontrol herbal for Treating Alcohol Abuse

    SBC: NATURAL PHARMACIA INTERNATIONAL, INC.            Topic: 350

    This application for a Fast Track STTR award represents a collaboration between Natural Pharmacia InternationalIncNPIand McLean Hospital to initiate steps toward commercializing a isoflavone botanical product for treating alcoholismExcessive use of alcohol accounts for much of the public health burden related to alcohol use disordersincluding fetal alcohol syndromefatal motor crashesaccidents and ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A Unified System for Wireless Optogenetics and Brain Microdialysis for Small Molecules Prototype Development and Validation

    SBC: AMUZA, INC            Topic: 101

    PROJECT SUMMARY While optogenetics is well suited for understanding the dynamic activity of neural circuits the first central theme of the NIH BRAIN Initiative PAR its neurochemical impacts remain largely uncharacterized due to a lack of appropriate tools Given that the predominant mode of cellular interactions is neurochemical commercial development of such tools will fulfill the ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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