Award Data

DESCRIPTION (Verbatim from the Applicant's Abstract): The specific aims of this Phase I STTR project, proposed by the American Magnetics, Inc. in partnership with the MIT Francis Bitter Magnet Laboratory, are: 1) experimental demonstration of feasibility of innovative design and operation features applicable to NMR Nb3Sn-magnet/cryocooler systems; and 2) co ...

DESCRIPTION (Applicant's Abstract): Primary pulmonary hypertension (PPH) is uniformly fatal and has no known cure. A major pathogenic factor in PPH is decreased synthesis of the vacillator prostaglandin 12 (PG 12) and excess synthesis of the vasoconstrictor prostanoid, thromboxane A2 (TxA2). The investigators have shown in an animal model of acute pulmona ...

DESCRIPTION (Applicant's Abstract): The investigators have developed a plasmid vector that expresses the normal human alpha-1 antitrypsin (AAT) gene in human respiratory epithelium when delivered as a plasmid-cationic liposome complex. In subjects with inherited AAT deficiency, they showed that liposome mediated transfer of the normal AAT gene to the nasal respiratory epi ...

DESCRIPTION (provided by applicant): The overall goal of this project is to develop a novel approach for the treatment of drug abuse using unique and patented biodegradable injectable gel formulations which can control the release of naltrexone. These novel biodegradable get formulations wit maintain therapeutic concentrations of naltrexone for at least 4 week ...

DESCRIPTION: (Applicant's description) Combinatorial methods for the synthesis of new drug substances require high throughput techniques for evaluation of structure-activity relationships. Microliter plates with immobilized target receptors can rapidly reduce thousands of possibilities to hundreds of candidates. The next level of screening has proven to be mor ...

DESCRIPTION(Adapted from applicant's abstract): One of the most disabling sequelae to brain injury (BI), stroke, cerebral palsy (CP), spinal cord injury (SCI), spinal degenerative diseases such as multiple sclerosis (MS) and familial spastic paraparesis is the development of spastic hypertonia. The systemic delivery of gamma-amino-butyric aci ...

DESCRIPTION (provided by applicant): This project will design, develop and evaluate an interactive multimedia program to provide integrated instruction about the embryology and anatomy of the adult human central nervous system. The program will also provide extensive self-testing for the competencies to be acquired through interaction with the software program. The ...

DESCRIPTION (provided by applicant): Based on the extensive data generated during the phase I portion of our studies, there is sufficient and compelling information to support the further development of the highly lipophilic and blood-stable topoisomerase inhibitor, DB-67. In part, the pre-clinical and clinical evaluation of DB-67 is currently being supported by ...

DESCRIPTION (provided by applicant): Based on the extensive data generated during the phase I portion of our studies, there is sufficient and compelling information to support the further development of the highly lipophilic and blood-stable topoisomerase inhibitor, DB-67. In part, the pre-clinical and clinical evaluation of DB-67 is currently being supported by ...

DESCRIPTION (PROVIDED BY APPLICANT): DB-67 is a promising new silatecan (silylcamptothecin) analog that displays superior blood stability relative to the FDA-approved camptothecin congeners, topotecan and CPT- 11. DB-67 also exhibits a high degree of anti-cancer potency both in vitro and in vivo. DB-67 is a highly lipophilic camptothecin and active lactone levels pe ...