Award Data

Abstract In this Commercialization Readiness Pilot CRP Program application we propose to commercialize and bring to market EyeArt a fully automated high throughput retinal image analysis based diabetic retinopathy DR screening tool which has been developed and already validated in bench tests on very large real world data by developing and executing a market access plan conducting a pi ...

ABSTRACT Currently there are no FDA cleared molecular based tests for urinary tract infection UTI pathogen identification and antimicrobial susceptibility testing to replace the andapos gold standardandapos of dipstick urinalysis and urine culturing All pathogen identification tests still rely on clinical isolates from urine cultures largely unchanged from Kochandapos s postulates developed ...

DESCRIPTION provided by applicant The Fontan procedure or total cavopulmonary connection TCPC is a standard palliative surgery for patients with complex single ventricle congenital heart anomalies TCPC connects the inferior and superior vena cava IVC and SVC directly to the right pulmonary artery bypassing the heart The single ventricle is then reserved for pumping oxygenated blood to th ...

DESCRIPTION provided by applicant Human metagenomics the study of our bodyandapos s microbial and viral communities through next generation sequencing is transforming current paradigms of both health and disease Direct sequencing of microbiome populations has enormous potential for direct use in the diagnosis and epidemiology of infectious disease and for furthering our understanding of th ...

Abstract Alzheimerandapos s disease AD is the most common dementia in the elderly Currently there is no cure for the disease Pathologically AD is characterized by the presence of extracellular amyloid A plaques and intracellular tau neurofibrillary tangles in patientandapos s brain Although being vigorously pursued multiple attempts targeting on A generation clearance have been fail ...

Project Summary Repair of pectus excavatum sunken Chest currently involves a major surgical repair accompanied by a day post operative hospital stay and outpatient treatment with prescription pain medication We have created the Magnetic Mini Mover System which utilizes magnetic force to reconfigure the patientandapos s abnormal chest The implanted magnet is placed during a minute out ...

PARP inhibitors PARPi are particularly efficacious in tumors deficient in the BRCA tumor suppressor genes but of limited activity in BRCA competent tumors There is an unmet medical need to develop targeted therapeutic agents which will augment PARPi activity for BRCA wild type cancers and to increase chemo radiosensitivity in these malignancies BRCA proteins are essential components ...

SMALL MOLECULE THERAPEUTICS FOR ALZHEIMERandapos S DISEASE SUMMARY Alzheimerandapos s disease AD is a progressive and fatal neurological disorder that affects approximately one tenth of the population over the age of There is currently no cure for the disease The pathological hallmarks of the disease include the formation and accumulation in the brain of amyloid A Earlier therapeut ...

ABSTRACT Large banks of archived human tumor tissues including cancer biopsies harbor enormous amounts of disease relevant information that may facilitate development of novel therapeutic approaches and assist in our basic understanding of fundamental biological processes However the resource is clearly underused due to a number of technical challenges associated with the retrieval of molecular ...

Abstract Brain swelling is a serious complication of multiple disease conditions including liver failure metastatic tumors traumatic brain injury and ischemic stroke TBI and stroke afflict M and K persons per year in the US alone and is a costly health care burden and a devastating social burden Current treatments for brain swelling are limited and generally ineffective highligh ...