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Extra anatomic bypass or vascular shunts divert blood flow In congenital heart disease these surgical procedures are critical for management Children born with one functional ventricle or cardiac pumping chamber require two to three major cardiac surgery procedures for palliation The management goal is to divert systemic venous return deoxygenated blood from the heart directly to pulmonary a ...

Toxicological assessments rely on low throughput costly animal studies that deliver minimal insights into compound toxicity mechanisms Induced pluripotent stem cells iPSCs are positioned to transform the evaluation of toxic compounds by enabling predictive physiologically relevant model systems compatible with high throughput screening Combining these iPSC benefits with high content screenin ...

Circulating tumor DNA ctDNA is a promising biomarker for noninvasive diagnostic prognostic and follow up tests for cancer However the relatively low quantity of ctDNA and the rare cancer mutations within large excess of wild type DNAs have presented many challenges for its application in the clinic The goal of the research is to develop our magnetic nanobeads and highly fluorescent magnet ...

A great challenge in microscopic imaging of biological and medical samples e g tissue sections is to achieve high sensitivity high specificity high multiplexing and high resolution preferably beyond the diffraction limit simultaneously This SBIR proposal addresses this challenge by developing a novel technology platform called Proximity DNA Exchange Imaging As a result of the studies pro ...

Proximity technology motivated by an array of potential applications offers a robust foundation for the development of cell type specific quantitative intramolecular epitopes of analytes in tissue sections In this proposal we highlight how our CamelTM dual peaks quantum dots QDs are greatly suitable fluorophores with spectroscopic properties that can be controlled via fluorescence resonance ...

The availability of liquid biopsies such as sampling of blood to measure key disease biomarkers could aid in the detection of blood circulating tumor DNA ctDNA known to confer resistance to cancer therapy For example the T M mutation in the epidermal growth factor EGFR accounts for of acquired resistance to FDA approved EGFR targeted therapies Detection of this mutation is important ...

In different individuals exposed to radiation radiation will cause variable levels of rapid combined tissue death cell apoptosis and necrosis leading to toxicity This acute tissue loss correlates with radiation injury DiaCarta sRadTox QuantiDNATMdiagnostic product measures tissue loss and is related to radiation dose field size knownsensitive organ exposure and use of sensitizers RadTox Qua ...

Cancer survivors commonly report cognitive impairments following chemotherapy With a growing number of cancer survivors comes an increased urgency to better understand the precise etiology and prevalence of cognitive changes associated with cancer and cancer treatment This pursuit is impeded by a lack of assessment tools that can accurately detect the full scope of cognitive deficits To address ...

We propose to demonstrate the feasibility of a novel highly multiplexed targeted sequencing based Liquid Biopsy TempO Seq Assay to measure cell free circulating DNA cfNA from plasma samples the cfNA TempO Seq assay We will exploit the single base specificity of TempO Seq to measure SNVs and other mutations and measure microsatellite short tandem repeats and methylation with modifications to th ...

To develop a coccidiomycosis vaccine