Award Data

ABSTRACT: A novel human coronavirus, which causes severe acute respiratory disease, now known as SARSCoV-2 emerged in December 2019. Infection with SARS-CoV-2 spread rapidly worldwide and on 11 March 2020 it was declared a pandemic by the World Health Organization. As of 4 September 2020, there are over 26 million confirmed cases of coronavirus infectious disease (COVID-19) caused by this new viru ...

ABSTRACT: Tuberculosis (TB) remains one of the most challenging diseases with ten million new cases and two million deaths yearly, and severe problems due to underdiagnosis and inadequate testing. A point-of-care (PoC) test for all kinds of TB that is sensitive, quick, simple, and not sputum-based is urgently needed. The most promising avenue to accomplish this is an immunoassay based on the TB bi ...

ABSTRACT: Teichos technology, amacromolecularplatformofpeptidoglycanbiologics(sPGN)producedbyproprietary chemoenzymatictotalsynthesis,offersimprovedinfluenzavaccinesthroughsignificantlyimprovedadjuvant performance. TL-001, a stimulatory sPGN, demonstrated adjuvant activity at low doses in standard laboratory vaccination model. We propose to evaluate TL-001 for its potential utility as an influenza ...

ABSTRACT:Infertility affects an estimated 8-12% of reproductive-aged couples, leading many to seek assisted reproductive technologies (ART) treatments such as in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and zygote intrafallopian transfer (ZIFT). Approximately 1.9% of infants born in the United States each year are conceived using ART. The Fertility Clinic Success Rate and ...

ABSTRACT: Tuberculosis (TB) is one of the top ten causes of death globally and is the second most powerful single infectious agent behind HIV/AIDS. While the incidence of TB continues to decrease every year, there has been a significant rise in drug resistant TB (DR-TB), with 10% of the cases developing into extensively drug resistant TB (XDR TB). The therapeutic outcome of these drug resistant TB ...

Pathogens reach the subarachnoid space (SAS) through the blood-stream, or from contiguous sites, and penetrate the blood-brain barrier though complex molecular and cellular mechanisms [1, 2]. For example, meningitis causes an imbalance between the water content of the brain parenchyma, CSF volume and cerebral blood flow thus resulting in a net increase of ICP [3]. Cerebral edema caused by inflamma ...

Ebolavirus species including Zaire (EBOV), Sudan (SUDV) and Bundibugyo (BDBV) are responsible for severe hemorrhagic fever outbreaks with high case fatalities in Africa [1,2]. Outbreaks of EBOV in the Democratic Republic of the Congo (DRC) as well as the 2014-2016 outbreak in West Africa highlight the danger that these zoonotic viruses pose through mucosal routes of infection and secondary human t ...

PROJECT SUMMARY With the rise of artificial intelligence (AI) algorithms in medicine, radiologists have new tools at their disposal to quantitatively assess imaging data. However, in order to unlock this potential, data needs to be shared easily and effectively between all parts of the health information technology (IT) system. The goal of this project is to reduce data access barriers by developi ...

Shrader, William D. Abstract: Alzheimerandapos;s disease (AD) is the largest unmet medical need in the US and the only major cause of death that cannot be prevented, cured, or slowed. Arviat Pharmaceuticals, Inc. is developing oral small-molecule inhibitors of the 12/15-lipoxygenase (12/15-LO) enzyme family to reduce microglia driven neuroinflammation and, thereby, slow progression of AD. Inhibiti ...

Abstract Approximately 43 million Americans suffer from osteopenia, a highly common skeletal condition defined by accelerated bone loss. If bone loss is not mitigated, patients become osteoporotic and are at increased risk of bone fractures, particularly of the hips and spine. Such fractures decrease independent living, shorten life, and increase morbidity. Clinical guidelines for treating osteope ...