Award Data

Pathogens reach the subarachnoid space (SAS) through the blood-stream, or from contiguous sites, and penetrate the blood-brain barrier though complex molecular and cellular mechanisms [1, 2]. For example, meningitis causes an imbalance between the water content of the brain parenchyma, CSF volume and cerebral blood flow thus resulting in a net increase of ICP [3]. Cerebral edema caused by inflamma ...

Ebolavirus species including Zaire (EBOV), Sudan (SUDV) and Bundibugyo (BDBV) are responsible for severe hemorrhagic fever outbreaks with high case fatalities in Africa [1,2]. Outbreaks of EBOV in the Democratic Republic of the Congo (DRC) as well as the 2014-2016 outbreak in West Africa highlight the danger that these zoonotic viruses pose through mucosal routes of infection and secondary human t ...

Human butyrylcholinesterase (BChE) is an effective bioscavenger of organophosphates and has potential for acting as a pre-exposure prophylactic or post-exposure treatment for organophosphate (OP) nerve agents, such as sarin. Ideally, a single dose of BChE could be administered and protect the warfighter for days or even weeks while in combat. To be effective in a military setting, especially as a ...

Arenaviruses comprise a diverse group of Old (Africa) and New World (Americas) species. Several species are associated with hemorrhagic fever (HF) with case-fatality rates as high as 30%. Arenavirus infections typically occur via the mucosal route through contact with excretions of an infected rodents or the inhalation of aerosolized particles from soiled rodent urine or saliva although direct hum ...

Dexai uses hygienic robot arms to automate food preparation activities, starting with the assembly of prepared ingredients commonly found in buffet or salad lines. Dexai's solution significantly reduces health risks for military personnel and food consumers, without compromising on taste or quality. Dexai’s plug-and-play solution consists of a commodity robot arm adapted to kitchen cleanliness s ...

The MK39 Expendable Mobile Anti-Submarine Training Target (EMATT) has become a vital tool in the Navy’s Anti- Submarine Warfare (ASW) tool kit by providing a low cost, expendable, open ocean, programmable, and modular training target, capable of simulating numerous types of submarine signatures and behaviors in the field for the training of submarine, aircraft, & ship crews in the search, detect ...

HELA Novel Metals LLC is a U.S. Corporation with no Chinese investments or technology affiliations. The company has developed an efficient and cost-effective technology for converting individual Rare Earth (RE) salts to pure metal powders. This game-changing technology was developed after 3 years of combined basic research and multiple advanced pilot testing programs at our company facility in Mas ...

As innovations and new technologies have been implemented into the acoustics, propulsion, payload, and sensor systems of EMATTs there has been an increasing need to reliably track and trace a variety of EMATT components throughout their supply chain. This need is further compounded by an increase in EMATT production volumes. The proposed technology from Triton Systems will address this need by pro ...

In order to limit the spread of contamination and restore combat operations, CBBD is requesting the development of a man-portable system which rapidly decontaminates items, such as sensitive equipment, etc. The decontamination system will be effective against a broad spectrum of biological agents (spores, bacteria, and virus) within minutes. The decontamination efficacy should be 99.9 percent redu ...

Infections of the central nervous system (CNS) are associated with brain swelling and increased cerebral blood volume, as well as focal cerebral perfusion deficits, variable levels of cerebral blood flow and cerebral vasculitis. The net result is increased intracranial pressure (ICP) along with significant risk of brain tissue herniation and ischemic syndromes. ICP monitoring is critical in the ma ...