Award Data

Performing accurate simulations of large- and multi-scale electromagnetics problems has far-reaching implications The same physics governs applications as diverse as rare earth content reduction in DC motor design; wireless propagation in dense urban environments and novel antenna design, both key issues in the pending 5G communications boom; electromagnetic sounding for subsurface exo-terrestrial ...

PROJECT SUMMARY The goal of this Phase I STTR is for Blotting Innovations, LLC to establish feasibility of a commercializable mesowestern—a high-throughput, affordable western blotting technique that we recently developed. Western blotting is a technique for molecular-weight-resolved analysis of proteins and their post-translational modifications that is practiced today almost identically to whe ...

DESCRIPTION (provided by applicant): Acid ceramidase (AC) has been implicated as a novel target for cancer therapy because of its pivotal role in regulating interconversion of three key bioactive lipids; ceramide (Cer), sphingosine (Sph) and Sphingosine-1-Phosphate (S1P). It is well known that Cer functions predominantly as a tumor suppressor lipid and mediator of apoptosis following chemo and rad ...

DESCRIPTION (provided by applicant): Propionibacterium acnes (P. acnes) is most notably recognized for its role in acne vulgaris, the most common skin disease, affecting 85-100% of the population at some point in their lives. Current treatments for vulgari s acne using isotretinoin (13-cis-retinoic acid) or antibiotics can have many undesirable effects, including depression, teratogenicity, hormon ...

A Continuous Low-Inventory Tritium Fuel Cycle for Fusion DOE Grant No. DE-FG02-98ER86075 Amount: $99,999 Small Business Cryogenic Applications F, Inc. 450 Bacon Springs Lane Clinton, TN 37716-5311 Dr. Christopher A. Foster, Principal Investigator Dr. Christopher A. Foster, Business Official (423) 435-5433 Research Institution Los Alamos National Laboratory MS C334 P.O. Box 1663 Los Alamos, NM ...

DESCRIPTION (provided by applicant): Reliable diagnostic differentiation between acute and chronic myocardial infarcts would be of great benefit for cardiac surgeons and interventional cardiologists. Such differentiation could be used to make decisions about which vessels and in what order would be reopened or bypassed. MRI is an intrinsically noninvasive diagnostic tool and the Delayed Enhancemen ...

DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

Oxide dispersion strengthened (ODS) steels are desired for Generation IV reactor core applications such as thin-walled claddings due to their improved elevated temperature strength and radiation properties. The high temperature resistance of the ODS steels is a result of uniformly dispersed oxide nanoparticles in a ferritic matrix. The oxide nanoparticles prevent grain boundary movement and pin di ...

DESCRIPTION (provided by applicant): Alzheimer disease (AD) is the most common neurodegenerative disease in the elderly. To date, no satisfactory treatment is available for AD. One of the pathological hallmarks of AD is deposits of amyloid protein (Aa) in neuritic plaques and cerebral vessels. Increasing lines of evidence support the notion that Aa and its precursor (APP) play pathogenetic roles i ...

The next generation of reactors will provide safe, reliable, and clean electricity as well as enable new applications for nuclear energy including hydrogen production, industrial heat generation, and water desalination. However, the design and operating characteristics of next-generation reactors (e.g. elevated temperatures, increased radiation, corrosive coolants, extended refueling cycles, compa ...