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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Administrative Supplement to restore fee funds

    SBC: AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.            Topic: NINDS

    Project Summary Traumatic brain injuryTBIcauses detrimental behavioral dysfunctions and brain neurodegeneration butunfortunatelythere currently is no effective pharmaceutical TBI treatmentThe underlying PhaseSTTR grant is to develop a new class of TBI drugs that inhibit the protease cathepsin BGenetically deleting the cathepsin B gene in mice results in substantial behavioral and pathology improve ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Advancing Formulation of STING agonist for Universal Flu Vaccine

    SBC: IMMvention Therapeutix, Inc.            Topic: NIAID

    Summary Influenza virusa member of the orthomyxovirus familyhas three different types that infect humansABand CTypes A and B produce annual epidemicsand type A influenzawhich resides asymptomatically in birdscan cause pandemic infections in humansIn addition to common flu like symptomse gfeverchillsmalaisemuscle painin susceptible populations influenza can induce potentially fatal secondary compli ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Amelioration of rhinovirus induced asthma exacerbations by serpin B1

    SBC: Serplus Technology, LLC            Topic: NIAID

    PROJECT SUMMARY Asthma exacerbations are a major cause of ER visits and hospitalizations with annual direct costs of approximately $billionyear in the USAViral infectionsin particular rhinoviralRVinfectionsare a major precipitant of asthma exacerbations in allergic asthmaticsAs there are overRV serotypes andfor nowno RV vaccinenovel strategies to inhibit RV induced airway inflammation are needed t ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. A NOVEL SELF-ASSEMBLING PROTEIN NANOPARTICLES-BASED GENITAL HERPES VACCINE

    SBC: Sunomix Therapeutics            Topic: NIAID

    ABSTRACTA staggering number of overbillion individuals worldwide are currently infected with herpes simplex virus typeand or typeHSVandampHSVwhich cause genital herpesMost HSV seropositive individuals are asymptomaticASYMPand never have any recurrent herpetic diseaseIn contrasta small proportion is symptomaticSYMPwith frequentoften lifelong bouts of recurrent herpetic diseasea result of reactivati ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. A Novel Therapeutic that Harnesses MIcrotubules to Enhance Corneal Wound Healing Following an Alkaline Burn

    SBC: MicroCures Inc.            Topic: NEI

    The cornea is one of the most important tissues in the eye and its transparency is critical for good visual function in humansCorneal tissue injuries are the most common everyday issue for practicing ophthalmologists and can run the gamut in severityIn severe modelssuch as corneal alkaline burnsextensive healing is needed and often the burn victim is left with reduced visual acuityHealing of large ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. A Novel Therapeutic that Harnesses Microtubules to Promote Cavernous Nerve Regeneration after Radical Prostatectomy

    SBC: MicroCures Inc.            Topic: 300

    Radical prostatectomyRPis a commonly used treatment option for localized prostate cancerUnfortunatelythe procedure carries a risk of post surgical complications including a high risk of erectile dysfunctionEDAccording to The Prostate Cancer Outcomes Studyvirtually all men experience ED after surgeryincluding a profound loss of nocturnal erectionsThe Prostate Cancer Outcomes Study further reveals t ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A scalable system for high throughput, chronic electrophysiology in translational rodent research

    SBC: Spikegadgets LLC            Topic: 101

    Psychiatric disorders give rise to aberrant patterns of activity within the complex neural circuits of our brainsYetthe exact nature of these abnormal patterns is often unknown to developers of new treatmentsThe goal of this project is to enable circuit oriented research of neuropsychiatric diseases using rodent disease modelsThe long term objective is to catalyze the discovery of new therapeutic ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. A software tool for objective identification of concussion-related vision disorders using a novel eye-tracking device

    SBC: Oculogica Inc            Topic: 102

    ABSTRACT This project will create the first objective measurement toolthe VisBoxfor the vision subtype of concussionVSCThis will enable physicians to identify VSC without an eye care professionalfor referral to a vision specialist for personalized vision therapy recommendationsThe persistence of concussion symptoms beyond several weeks is often a life altering situation for affected individualsand ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Astroglial EAAT2 Changes in Live TBI Brain Determined by PET Imaging

    SBC: RIO PHARMACEUTICALS, INC.            Topic: NINDS

    PROJECT SUMMARYTraumatic Brain InjuryTBIis one of the most significant Public Health trauma diseases of our timeDiagnoses of various TBI forms rely on patient self reportingestablished clinical rating scalesand multimodality imaging to an extentTBI elicits complexheterogeneous pathological eventsincluding mechanical injuryhemorrhageand progressive secondary processes such as central and peripheral ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. A user-friendly microfluidic chip for anti-epileptogenic drug screening

    SBC: Xona Microfluidics, Inc.            Topic: 101

    New pharmacological treatments for epilepsy will be discovered through the development of new screening platforms that are rapidreliableand can identify novel disease modifying therapiesor anti epileptogenic treatmentsXona MicrofluidicLLCXonais in a unique position to provide such screening tools and services for epilepsy researchXona focuses on the development of microfluidic platforms for neuron ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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