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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Identification of RORg drug candidates for the treatment of NASH

    SBC: VISIONARY PHARMACEUTICALS, INC.            Topic: 300

    ABSTRACT Significance An epidemic proportion of Americans approximately million suffer from obesity and nonalcoholic fatty liver disease a spectrum of progressive liver disease that include steatosis non alcoholic steatohepatitis NASH fibrosis and eventually cirrhosis and hepatocellular carcinoma HCC There is no standard of care pharmacotherapy for NASH Therefore new thera ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Small molecule activators of alpha crystallin for non surgical treatment of cataracts

    SBC: Plex Pharmaceuticals, Inc.            Topic: N

    Project Summary Cataract the clouding of the eye lens is responsible for of world blindness According to World Health Organization nearly million people are bilaterally blind from cataract in the world Cataract is easily treated by surgery and is considered as one of the most cost effective interventions Although cataract surgery is generally considered to be safe there are significan ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Multiplexed Point Of Care Nucleic Acid Assay for STI

    SBC: PHOENIX BIOSYSTEMS, INC.            Topic: NIBIB

    DESCRIPTION provided by applicant With nearly million new infections annually sexually transmitted diseases STDs are very common in the United States And with recent changes to the national health care landscape including the passage of the Affordable Care Act and state budget cuts resulting in the closure of STD and HIV clinics primary care providers can expect to encounter more patie ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Near patient molecular diagnostics test for infections

    SBC: GeneFluidics, Inc.            Topic: R

    ABSTRACT Currently there are no FDA cleared molecular based tests for urinary tract infection UTI pathogen identification and antimicrobial susceptibility testing to replace the andapos gold standardandapos of dipstick urinalysis and urine culturing All pathogen identification tests still rely on clinical isolates from urine cultures largely unchanged from Kochandapos s postulates developed ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Advanced Image Analysis Tools for Diabetic Retinopathy Telemedicine Application

    SBC: EYENUK, INC.            Topic: NEI

    Abstract In this Commercialization Readiness Pilot CRP Program application we propose to commercialize and bring to market EyeArt a fully automated high throughput retinal image analysis based diabetic retinopathy DR screening tool which has been developed and already validated in bench tests on very large real world data by developing and executing a market access plan conducting a pi ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Chikungunya Recombinant Subunit Vaccine

    SBC: Hawaii Biotech, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Chikungunya virus CHIKV is an alphavirus classified as a category C priority pathogen that causes fever rash and arthralgia in humans In the past decade CHIKV outbreaks have spread beyond the endemic regions of Africa and Asia first to the islands in the Indian Ocean and most recently to the Americas The World Health Organization has reported that as ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Assessing psychosis related deficits based on gaze behavior

    SBC: Eye-Predict            Topic: 101

    DESCRIPTION provided by applicant Assessing psychosis related deficits based on gaze behavior Existing tests of psychotic disorders are either functionally informative or biologically valid but rarely both The ultimate project goal is to improve behavioral health and reduce societal costs by providing a battery of user friendly tests that offer functional relevance couple with biological vali ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Isothermal Chain Reaction ICR Detection of SNP Biomarkers for Ovarian Cancer Pont of Care Testing and Risk Stratification

    SBC: GenEndeavor LLC            Topic: 102

    DESCRIPTION provided by applicant The long term objective of this application is to develop novel products for routine point of care POC genetic testing ranging from early cancer detection to pathogen identification by using an innovative biotechnology called Isothermal Chain Reaction ICR ICR is a disruptive and enabling technology platform that will offer a new class of reagents relevan ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. TelePCC Personalized Cognitive Counseling via Phone to Reduce HIV Risk in MSM

    SBC: ALLEN/LOEB ASSOCIATES            Topic: 105

    DESCRIPTION provided by applicant New intervention strategies are needed to prevent HIV transmission among men who have sex with men MSM who continue to account for two thirds of new HIV infections each year Effective behavioral interventions are available but the majority of at risk MSM do not receive them Most HIV prevention organizations are unable to deliver evidence based interventio ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Glycosaminoglycan Interacting Small Molecule GISMO as Parkinson s Therapeutic

    SBC: Gismo Therapeutics Inc.            Topic: 106

    Glycosaminoglycan Interacting Small Molecule GISMO As Parkinsonandapos s Therapeutics ABSTRACT Current approved drugs for Parkinsonandapos s Disease PD treat the symptoms of the disease but do not stop disease progression This project is focused on developing a new disease modifying PD therapeutic with a novel mode of action that is expected to block disease progression Recent data indicate ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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