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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Administrative Supplement to restore fee funds

    SBC: AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.            Topic: NINDS

    Project Summary Traumatic brain injuryTBIcauses detrimental behavioral dysfunctions and brain neurodegeneration butunfortunatelythere currently is no effective pharmaceutical TBI treatmentThe underlying PhaseSTTR grant is to develop a new class of TBI drugs that inhibit the protease cathepsin BGenetically deleting the cathepsin B gene in mice results in substantial behavioral and pathology improve ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. An epitope focused nanoparticle vaccine for MRSA and biodefense

    SBC: VLP BIOTECH, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Overall Staphylococcus aureus is a gram positive bacteria which possesses a multitude of virulence factors It is a frequent and severe pathogen in hospitals and of increasing concern in the community where it results in severe skin infections pneumonia bacterial endocarditis and sepsis A significant proportion of these infections are the result of methici ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Therapeutic that Harnesses MIcrotubules to Enhance Corneal Wound Healing Following an Alkaline Burn

    SBC: MicroCures Inc.            Topic: NEI

    The cornea is one of the most important tissues in the eye and its transparency is critical for good visual function in humansCorneal tissue injuries are the most common everyday issue for practicing ophthalmologists and can run the gamut in severityIn severe modelssuch as corneal alkaline burnsextensive healing is needed and often the burn victim is left with reduced visual acuityHealing of large ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Bitter Human Taste Bud Epithelial Cell Platforms for Bitter Taste Antagonist Discovery

    SBC: DISCOVERYBIOMED, INC.            Topic: NIDCD

    Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Monell Chemical Senses Center Project Summary Abstract Bitter taste in foods and medicines presents a barrier to overcoming global public health challengesfood insecuritypoor nutritional healthand poor compliance with medication useparticularly among children and the elderlySugar and saltthe mainstays to address these challengesfur ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Development and Validation of a Physical Anatomic Model for Surgical TrainingUsing 3D Printing Technology

    SBC: Simulated Inanimate Models LLC            Topic: NIBIB

    Project SummarySimulation training is unique in its ability for repetitive practice of a wide variety of scenarios and to reflect on performance without jeopardizing a patient s safetyMedical simulation provides a controlled setting with step wise skills progressionutilizing continuous feedback and assessment aiming at the ultimate goal of skills transfer to clinical competenceSurgical skills simu ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Dressing Assistant: Home Technology to Sustain Independent Dressing in Dementia

    SBC: Inventors' Workshops, Inc.            Topic: NIA

    AbstractPersons living with dementiaPWDoften require assistance with routine activities and daily tasksWorkloads placed on caregivers often results in high levels of physical and emotional stressand depressionand higher overall morbidity and mortality ratesFocus group of caregivers for individuals with mild to moderate dementiaidentified dressing the PWD as the most pressing and stressful daily co ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Enhanced Software Tools for Detecting Anatomical Differences in Image Data Sets

    SBC: Kitware, Inc.            Topic: 105

    Project SummaryMorphometric analysis is a primary algorithmic tool to discover disease and drug related effects on brain anatomyNeurological degeneration and disease manifest in subtle and varied changes in brain anatomy that can be non local in nature and effect amounts of white and gray matter as well as relative positioning and shapes of local brain anatomyState of the art morphometry methods f ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Evaluation of a Novel Infection PET Diagnostic

    SBC: CHRONUS PHARMACEUTICALS, INC.            Topic: NIBIB

    Project Summary Abstract Bacterial infections such as those of prosthetic jointsbonesosteomyelitisand heart valvesinfective endocarditisare difficult to difficult to diagnose and treatand are a major cause of mortalitymorbidity and health care costsThe long term goal of our program is thus to develop positron emission tomographyPETradiotracers that can be used for non invasive PET imaging to detec ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications

    SBC: GENECAPTURE            Topic: CBD15C001

    The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust molecula

    STTR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  10. Innovative Nose-to-Brain Anticancer Drug Transport Facilitated by NEO100

    SBC: Neonc Technologies, Inc.            Topic: 102

    Project Summary Abstract Many pharmaceutical agents are highly potentbut are unable to exert substantial therapeutic activity against disorders of the brainbecause the blood brain barrierBBBeffectively prevents their access to the site of intracerebral diseaseFor examplethe majority of glioblastoma patientsdespite the best efforts of current medical caredie within two years after diagnosisHencethe ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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