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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Accurate and efficient density functional theory calculations of intermolecular interactions and conformational energies

    SBC: Q-CHEM, INC.            Topic: 100

    Project summary Key biophysical properties such as drug binding sites and enzyme catalysis arise can be computer modeled using quantum mechanics but limitations in the accuracy of practical quantum methods have held back progress Over the past five years this situation has changed with exciting and ongoing improvements in the accuracy of density functional theory DFT New and better densit ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A device to reduce catheter related bloodstream infection rates in patients with peripherally inserted central catheters PICCs

    SBC: Puracath Medical, INc            Topic: NIAID

    ABSTRACT PuraCathandapos s goal is to develop an FDA approved catheter hub disinfection system for peripherally inserted central catheter PICC that dramatically reduces catheter related blood stream infections CRBSIs using LED Ultra Violet UV light In Phase I of this SBIR project we propose to optimize the ease of use and robustness to enable home use The current CRBSI infection rate is e ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Advanced Image Analysis Tools for Diabetic Retinopathy Telemedicine Application

    SBC: EYENUK, INC.            Topic: NEI

    Abstract In this Commercialization Readiness Pilot CRP Program application we propose to commercialize and bring to market EyeArt a fully automated high throughput retinal image analysis based diabetic retinopathy DR screening tool which has been developed and already validated in bench tests on very large real world data by developing and executing a market access plan conducting a pi ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Advanced method for preparing cell free DNA sequencing libraries

    SBC: Somagenics, Inc.            Topic: NHGRI

    The goal of the proposed research is to develop an improved method RealSeq DC to prepare libraries of cell free DNA cfDNA for next generation sequencing NGS cfDNAs which are found in blood and in other bodily fluids represent promising minimally invasive liquid biopsy samples for human cancer and prenatal diagnosis of fetal genetic diseases cfDNAs comprise highly fragmented double str ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Advancing Allosteric CaMKII Inhibitors to Treat Multiple Novel Pathways in Diabetes

    SBC: ALLOSTEROS THERAPEUTICS, INC.            Topic: 200

    Type diabetes mellitus has become a worldwide epidemic with significant human and economic burdens Diabetic patients are particularly at risk of mortality from myocardial infarction and it is therefore important that glucose lowering is achieved by drugs that do not further compromise the heart Evidence now supports Ca calmodulin dependent protein kinase II CaMKII a mediator Ca signalin ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A facile approach for preparing dual agonists with long lifetimes and balanced activities

    SBC: Prolynx, LLC            Topic: 200

    We have developed a chemically controlled ultra long acting delivery system to support once weekly to once monthly administration of peptides In this system the peptide is covalently attached to a hydrogel microsphere depot by a cleavable eliminative linker upon subcutaneous injection the linker slowly cleaves and releases the drug If the same linker is used to attach two different peptide ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A functional genomics tool for high throughput cell free analysis of regulatory components

    SBC: SYNVITROBIO, INC.            Topic: NHGRI

    Project Summary Here we seek to develop a novel functional genomics tool a RNA Polymerase II dependent RNAPII eukaryotic cell free expression system that allows for rapid characterization of human regulatory components There is a pressing need for new tools that can analyze the exponentially increasing amount of genomic data that has been collected through NHGRI sequencing initiatives and thr ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Green and Unique Thermosetting-Thermoplastic Polycarbonate

    SBC: INSTRUMENTAL POLYMER TECHNOLOGIES, LLC            Topic: 16NCER2B

    Of the 300 million tons of plastic produced per year most will take over 100 years to biodegrade. Though there is a growing ability to recycle thermoplastic, there is a 3.7% annual growth in the 50 million tons of thermoset plastic which can't be recycled. _x000D_ _x000D_ This project will develop a completely sustainable aliphatic polycarbonate plastic that is uniquely a recyclable thermoset resi ...

    SBIR Phase I 2017 Environmental Protection Agency
  9. A mucosally targeted MERS CoV vaccine produced in plants

    SBC: Planet Biotechnology Incorporated            Topic: NIAID

    DESCRIPTION provided by applicant Middle East Respiratory Syndrome MERS coronavirus MERS CoV causes severe acute respiratory illness with a high fatality rate among reported cases MERS was first reported in but the virus has been circulating in camels which are thought to be an animal reservoir for at least years To date over MERS cases have been reported to the World Hea ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. An epitope focused nanoparticle vaccine for MRSA and biodefense

    SBC: VLP BIOTECH, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Overall Staphylococcus aureus is a gram positive bacteria which possesses a multitude of virulence factors It is a frequent and severe pathogen in hospitals and of increasing concern in the community where it results in severe skin infections pneumonia bacterial endocarditis and sepsis A significant proportion of these infections are the result of methici ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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