Award Data

DESCRIPTION provided by applicant The neuromuscular assessment of children is uniquely challenging Unlike examination of the heart or lung the complete bedside assessment of the neuromuscular system requires the active participation of the child and results must be evaluated in the context of normal child development and degree of cooperation Moreover neuromuscular disease severity is highl ...

DESCRIPTION provided by applicant This study aims to develop an improved neonatal hearing screening device that will incorporate novel testing procedures combining simultaneous air and bone conduction testing so that mild hearing losses andlt dB nHL are better and consistently detected The proposed device will address the current need for a more sensitive hearing screening tool by stimul ...

DESCRIPTION provided by applicant Acute pesticide poisoning remains a vast health problem in the developed and developing world Domestically a study estimates that of every US agricultural workers suffer from acute pesticide poisoning On top of that long time effects have also been observed with an increased risk for lymphomas and prostate brain leukemia cervix and stomac ...

DESCRIPTION provided by applicant Non small cell lung cancer NSCLC is the most common lung cancer Half of NSCLC shows WNT activation marking poor survival StemSynergy Therapeutics Inc SSTI has identified a family of WNT inhibitors based on a novel chemical scaffold with our lead molecule SST demonstrating efficacy against WNT driven colorectal cancer In Phase I SBIR studies many ...

DESCRIPTION provided by applicant Bladder cancer BCa is among the five most common malignancies worldwide In the US alone new BCa cases for are estimated at with estimated deaths at At presentation the majority of bladder tumors are non muscle invasive and can be treated by transurethral resection of the tumor however more than of patients with BCa will have a re ...

DESCRIPTION provided by applicant The corneal endothelium plays a pivotal role in maintaining corneal transparency Unlike in other species the human corneal endothelium is notorious for its limited proliferative capacity in vivo after diseases injury aging and surgery Persistent corneal endothelial dysfunction leads to sight threatening bullous keratopathy Presently the only solution to ...

This project aims to optimize the lead formulation of epothilone D encapsulated in a stable nanoparticle for the treatment of solid malignancies, and assist in providing for the GMP manufacturing and GLP toxicology studies required for IND submission and translation into human clinical trials. The optimized formulation should demonstrate improvements in plasma pharmacokinetics in a cannulated rat ...

Not Available

DESCRIPTION provided by applicant Multiple myeloma MM is the second most commonly diagnosed hematologic malignancy with an estimated newly diagnosed cases and deaths due to MM in the United States in MM typically a disease of the elderly is a malignancy of clonal plasma cells in the bone marrow BM characterized by the presence of paraproteinemia destructive bone dise ...

DESCRIPTION provided by applicant Bladder cancer is the fifth most common cancer in the United States Over of patients initially present with non muscle invasive bladder cancer NMIBC confined to the mucosa of the bladder These patients are treated by tumor resection followed by intravesical chemotherapy or Bacillus Calmette Gu rin BCG therapy Despite treatment of NMIBC pat ...