Award Data

DESCRIPTION (provided by applicant): Globally, an estimated 16.2% of the human population is infected with HSV-2 including gt17% of the U.S. adult population. Genital herpes is associated with an increased risk of HIV acquisition and transmission and HSV-2infection can cause neonatal herpes with high infant mortality. HSV-2 infection in the adult population has increased substantially in the past ...

DESCRIPTION provided by applicant Globally an estimated of the human population is infected with HSV including andgt of the U S adult population Genital herpes is associated with an increased risk of HIV acquisition and transmission and HSV infection can cause neonatal herpes with high infant mortality HSV infection in the adult population has increased substantially in the ...

DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

DESCRIPTION (provided by applicant): This project aims to continue development and validation of a novel microfluidics device developed during Phase I that preserves the maximal viability, recovery, and function of cord blood hematopoietic stem cells (HSC). Allogeneic HSC transplantation is the elective treatment for over 50 life threatening diseases including leukemia and lymphoma. However due to ...

DESCRIPTION provided by applicant Claustrophobia and disruptive patient motion longtime common impediments to MRI examination can be prevented or ameliorated with a non pharmacologic behavioral intervention administered by trained staff The potential benefits of such an intervention are highly significant as current practice alternatives are to cancel the study or administer sedation Inabilit ...

DESCRIPTION provided by applicant The proposed research focuses on the development of a DNP NMR system for Dynamic Nuclear Polarization DNP enhanced solid state NMR spectroscopy at MHz High resolution structures are essential to the understanding of the complex functions of bio macromolecules and NMR spectroscopy is a major source for such information However the method suffers from an ...

DESCRIPTION provided by applicant A mobile based intervention to improve adolescentsandapos headache self management Abstract Headache pain is a common and significant problem for adolescents King et al As headaches become more frequent and severe the negative impact on happiness increases and adolescents report less satisfaction with their health and with their life Sillampaa ...

Contrast media (CM) induced nephropathy (CIN) remains prevalent and debilitating, the third most common cause of acute renal failure. Based on more than 80 million (M) CM injections in the USA per annum, of which 10% take place in a population highly susceptible to the development of CIN, and a unit pricing of 200 per course, we estimate the total domestic potential market equals 1.6B. At presen ...

DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI) is completing a Phase II program demonstrating a compact research instrument that integrates adaptive optics (AO) into a line scanning ophthalmoscope (LSO). The bench-top AO-LSO instrument significantly reduces the size, complexity, and cost of research AO scanning laser ophthalmoscopes (AOSLO), with the goal of transitioning adapti ...