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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Portable Phage Preparation Technology for Field Application

    SBC: CFD RESEARCH CORPORATION            Topic: A20BT023

    Bacteriophages (phages) are becoming important therapeutic candidates against multidrug resistant (MDR) bacterial infections. There is a need to isolate and concentrate phages collected from the field to enhance specimen storage stability for long-distance transport to specialized laboratories for subsequent analysis. Environmental phage preparation requires expensive, bulky instrumentation and in ...

    STTR Phase II 2023 Department of DefenseDefense Health Agency
  2. Flexible Microfluidic Process Technology for Biopharmaceutical Purification of Bacteriophages

    SBC: CFD RESEARCH CORPORATION            Topic: DHA21C002

    Multidrug resistant (MDR) bacterial wound infections remain a persistent challenge for front-line military medical providers in prolonged care treatment. Bacteriophage (phage) therapeutics have demonstrated preclinical and clinical efficacy against ESKAPEE infections. Phage production however remains a challenge to remove common pyrogen contaminants from phage products, including endotoxins (lipop ...

    STTR Phase II 2023 Department of DefenseDefense Health Agency
  3. Develop and demonstrate a technology for isolation of bacteriophages with enhanced antibiofilm activity

    SBC: CFD RESEARCH CORPORATION            Topic: DHA20B003

    The twenty-first century has seen a global rise in bacterial infections exhibiting antimicrobial-resistance (AMR). More than ninety percent of chronic wounds contain microbial biofilms that exhibit AMR, and the bacteria responsible for several of these recalcitrant infections are called ESKAPEE pathogens. Eradicating ESKAPEE pathogenic infections is challenging, but bacteriophage (phage) therapy i ...

    STTR Phase II 2022 Department of DefenseDefense Health Agency
  4. Inspire- In-Mask Sensors for Physiological Investigation of Respiratory Exhalation

    SBC: MAKEL ENGINEERING, INC.            Topic: DHP16C002

    High concentrations of supplemental oxygen are used routinely by pilots and divers prior to and during missions to prevent and treat decompression sickness, avoid detection during covert operations, and to support oxygenation following pulmonary injury. Due to pulmonary oxygen toxicity (PO2T), exposure limits are imposed to prevent damage to pulmonary tissues. Current policy focuses on preventing ...

    STTR Phase II 2021 Department of DefenseDefense Health Agency
  5. Flexible Microfluidic Process Technology for Biopharmaceutical Purification of Bacteriophages

    SBC: CFD RESEARCH CORPORATION            Topic: DHA21C002

    Multidrug resistant (MDR) bacterial wound infections remain a persistent challenge for front-line military medical providers in prolonged care treatment. Phage therapeutics have demonstrated preclinical and clinical efficacy against ESKAPEE infections. Phage production however remains a challenge to remove bacterial remnants including LPS endotoxins and other pyrogens. To meet regulatory requireme ...

    STTR Phase I 2022 Department of DefenseDefense Health Agency
  6. Novel Circulating RNA-based Markers as Diagnostic Biomarkers of Infectious Diseases

    SBC: CFD RESEARCH CORPORATION            Topic: CBD18A001

    In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens, whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial and alphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable an ...

    STTR Phase II 2020 Department of DefenseOffice for Chemical and Biological Defense
  7. ECCCHO: Effective Combat Casualty Care Handoff Operations

    SBC: TIER 1 PERFORMANCE SOLUTIONS LLC            Topic: DHA17B002

    According to the Joint Commission, approximately 70% of sentinel events in medical care are related to communication mishaps, and despite regular and frequent occurrence, poor communication during patient handoffs (i.e., transfer of patient care information, responsibility, and authority from one provider to another) remains a major contributor to medical errors (Nether, 2017; The Joint Commission ...

    STTR Phase II 2021 Department of DefenseDefense Health Agency
  8. Marburg Virus Prophylactic Medical Countermeasure

    SBC: MAPP BIOPHARMACEUTICAL, INC.            Topic: CBD18A002

    There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...

    STTR Phase II 2020 Department of DefenseOffice for Chemical and Biological Defense
  9. Marburg Virus Prophylactic Medical Countermeasure

    SBC: Flow Pharma, Inc.            Topic: CBD18A002

    Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...

    STTR Phase II 2020 Department of DefenseOffice for Chemical and Biological Defense
  10. Functional Engineering of a Photosynthetic Desalination Pump Circuit

    SBC: Phytodetectors, Inc.            Topic: G

    Phytodetectors will design and engineer a synthetic biological pump circuit to increase the volume of water produced via photosynthetic desalination. This project builds off previous technology designed by Phytodetectors: a mangrove-inspired ultra-filter that allows plants to purify salt water as well as secrete water with properties comparable to bottled water. The partnership seeks to demonstrat ...

    STTR Phase II 2021 Department of EnergyARPA-E
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