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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Automated Mental Health Referral System

    SBC: MiResource, Inc.            Topic: 104

    This proposal addresses a significant barrier to obtaining treatment for college-ageyouth with mental disorders. Many college-age youth with impairing mental disordersremain untreated because of concerns about stigma and privacy, inconvenience and wait times, andbecause universities are often unable to service all such students. Also, of critical importance,when referral for treatment is implement ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Multiplexed CRISPR-based immune cell RNA profiling by flow and mass cytometry

    SBC: Dahlia Biosciences, inc.            Topic: NIAID

    Project Summary/Abstract Immune cell profiling is crucial towards understanding key changes in host immune cell subpopulations and functions underlying SARS-CoV-2 viral clearance and immune-mediated pathology. This data will be essential towards the urgent development of COVID-19 diagnostics, therapeutics, and vaccines. Recent publications have showcased the power of scRNA-Seq immune cell profilin ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow

    SBC: Sigray, Inc.            Topic: 400

    Project Summary/Abstract Low oxygen (hypoxic) environments are known to be important for maintaining the small number of adult stem cells in the human body, such as in bone marrow. These conditions are also believed to enable dormant cancer cells to survive and metastasize years or decades after the original tumor has been destroyed and the reason why bone marrow is one of the most common sites of ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. A SARS-CoV-2 Breathalyzer for Direct Virus Detection

    SBC: Aerosol Devices Inc.            Topic: NIDCR

    Project Summary A substantial and growing body of evidence has demonstrated that COVID-19 is transmitted by human-emitted airborne particles; therefore, it is critical to rapidly screen individuals to determine whether they are at risk of transmitting the disease to others before they enter large venues (e.g., airports, schools) and smaller ones where extended exposure or close proximity is expect ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: NIMH

    Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations in holographic photostimulation. Specifically, the proposed innovations aim to achieve streaming of high-resolution holograms at up to 10,000 frames per second (fps) to enable closed-loop optogenetic control.Optical imaging and photostimulation have emerged as compl ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Identifying novel targets for cardioprotection with non-traditional animal models

    SBC: FAUNA BIO INCORPORATED            Topic: NHGRI

    Project Summary/Abstract:Low-cost sequencing has ushered in a new era of drug discovery that can that utilize genomic information from hundreds of thousands of people. However, humans are a limited resource for identifying novel drug targets, and attempts at therapeutic development often rely on an already well-known set of genes and pathways. Greater potential for discovery exists if we broaden o ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Micro-Supercapacitor for Integration with MEMS Energy Harvesting and CMOS ICs

    SBC: CFD RESEARCH CORP            Topic: DMEA21A001

    percapacitors provide energy densities comparable to thin film batteries, high power densities, ultrafast recharge, and long cycle lives for applications requiring high duty cycle and pulse power output.  Micro-supercapacitors (MSC) are the most promising energy storage technology for integration with energy harvesting, via micro-electro-mechanical systems (MEMS), and microelectronics integrated ...

    STTR Phase I 2021 Department of DefenseDefense Microelectronics Activity
  8. Critical angle reflection imaging for label-free quantification of molecular interactions

    SBC: BIOSENSING INSTRUMENT INC            Topic: 400

    TITLE: Critical angle reflection imaging (CARi) for label-free quantification of molecular interactions SUMMARYMeasuring molecular interactions of proteins are critical for understanding protein functions and cellular processes, for discovery and validating biomarkers, and for developing and screening drugs. In particular, membrane proteins play key roles in many cellular functions and are the lar ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Leveraging an academic-industry partnership to develop a cancer-specific mobile meditation app

    SBC: Calm.com, Inc.            Topic: 102

    1 Project Summary/Abstract2 Approximately 15.5 million US cancer patients/survivors experience a host of residual symptoms (e.g.,3 fatigue, anxiety, depression, pain, sleep disturbance) and reduced quality of life that are often not resolved with4 even the best-available current standard of care therapies. Residual symptom burden impairs cancer survivor5 functioning and leads to increased rates of ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. A novel approach to Mesenchymal Stem Cell Transduction

    SBC: Ossium Health, Inc.            Topic: NHLBI

    PROJECT SUMMARY Mesenchymal stem cells (MSC) are in clinical development for cardiovascular, neurologic, orthopedic, and other indications. Ossium is developing a novel source of MSC from vertebral bodies (vbMSC). Genetic modification of vbMSC using lentiviral vector (LV) has the potential to improve the therapeutic potential. Understanding how genetic modification might alter the vbMSC phenotype ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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