Award Data

Bacteriophages (phages) are becoming important therapeutic candidates against multidrug resistant (MDR) bacterial infections. There is a need to isolate and concentrate phages collected from the field to enhance specimen storage stability for long-distance transport to specialized laboratories for subsequent analysis. Environmental phage preparation requires expensive, bulky instrumentation and in ...

This program will develop and demonstrate a novel modular, continuous synthesis platform that can be rapidly reconfigured to produce multiple classes of energetic materials. Continuous synthesis of energetic materials has clear safety advantages, but current approaches are slow to realize due to long process development timelines. The proposed program will develop a system integration and control ...

Multidrug resistant (MDR) bacterial wound infections remain a persistent challenge for front-line military medical providers in prolonged care treatment. Bacteriophage (phage) therapeutics have demonstrated preclinical and clinical efficacy against ESKAPEE infections. Phage production however remains a challenge to remove common pyrogen contaminants from phage products, including endotoxins (lipop ...

Ultra-Wide bandgap materials such as GaN and Ga2O3 are emerging as preferred materials in high power applications due to their high breakdown field. The thermal dissipation is poor in both those materials due to low thermal conductivity. A high thermal conductivity material such as SiC is used as a growing substrate, however, the thermal conductivity is still limited due to defects in the interfac ...

This program will develop and demonstrate a novel modular, continuous synthesis platform that can be rapidly reconfigured to produce multiple classes of energetic materials. Continuous synthesis of energetic materials has clear safety advantages, but current approaches are slow to realize due to long process development timelines. The proposed program will develop a system integration and control ...

Multidrug resistant (MDR) bacterial wound infections remain a persistent challenge for front-line military medical providers in prolonged care treatment. Phage therapeutics have demonstrated preclinical and clinical efficacy against ESKAPEE infections. Phage production however remains a challenge to remove bacterial remnants including LPS endotoxins and other pyrogens. To meet regulatory requireme ...

The twenty-first century has seen a global rise in bacterial infections exhibiting antimicrobial-resistance (AMR). More than ninety percent of chronic wounds contain microbial biofilms that exhibit AMR, and the bacteria responsible for several of these recalcitrant infections are called ESKAPEE pathogens. Eradicating ESKAPEE pathogenic infections is challenging, but bacteriophage (phage) therapy i ...

According to the Joint Commission, approximately 70% of sentinel events in medical care are related to communication mishaps, and despite regular and frequent occurrence, poor communication during patient handoffs (i.e., transfer of patient care information, responsibility, and authority from one provider to another) remains a major contributor to medical errors (Nether, 2017; The Joint Commission ...

High concentrations of supplemental oxygen are used routinely by pilots and divers prior to and during missions to prevent and treat decompression sickness, avoid detection during covert operations, and to support oxygenation following pulmonary injury. Due to pulmonary oxygen toxicity (PO2T), exposure limits are imposed to prevent damage to pulmonary tissues. Current policy focuses on preventing ...

In emergency medicine, time is a critical factor that can significantly influence the survival of seriously ill patients. Early recognition of clinical deterioration and rapid initial management is paramount in any setting where emergency care is provided. In military medicine and humanitarian care, delivering high quality and timely care to injured patients poses even greater and more complex cha ...