Award Data

Abstract This proposal will lead to a Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of sub micron confocal photothermal IR micro spectroscopy CPIR Label free sub micron chemical imaging and spectroscopy has long been sought for visualization of biomolecules and materials in complex living systems Many diseases first manifest ...

Summary Drug safety issues pose a serious challenge to the health and well being of patients The development of our innovative technology aims to address a significant gap in the in vitro assessment of drug induced cardiotoxicity which is the number one reason for withdrawals of all marketed drugs as well as the premature termination of promising drug development candidates Pressured by the eno ...

ABSTRACT Traditional mon therapeutictarget driven approaches to drug development for Alzheimer s diseaseADare becoming increasingly expensive and in many cases disappointingly unsuccessfulBased on preliminary in vitro and in vivo studies we have identified a novel small moleculemethyldimethyloxodihydrobenzo cnaphthyridinecarboxylateBNCthat significantly decreases neuroinflammation and production o ...

SUMMARY Traumatic brain injury TBI is a leading contributor to death and disability in the USA yet widely effective treatments remain elusive and except for a lengthy program of rehabilitation no effective treatment for TBI is available Therefore there is a critical need in new therapeutic approaches which can maximally preserve brain tissue and facilitate functional recovery after TBI In ...

PROJECT SUMMARY Over million people worldwide including million people in the USA are HIV positive HIV associated sensory neuropathy HIV SN is the most frequent neurological manifestation of HIV and is characterized as a distal symmetrical predominantly sensory polyneuropathy HIV SN may represent clinically indistinguishable neuropathies with distinct pathogenesis a distal axona ...

We propose that the key to robotic automation in unstructured environments is compliant robotic manipulators that can tolerate, sense, and leverage contact in a feedback loop. We have demonstrated proof of concept of an instrumented end-effector capable of enhanced perception through observed and controlled contact in phase I. We will now expand the project to develop highly capable state and cont ...

The objective of this Phase 2 proposal is to provide a new set of sensitivity analysis theory and codes, the Sensitivity Analysis for Design Optimization (SADO) software that integrates with the existing NASA O3 Tool. In this Phase II effort, the sensitivity codes developed in Phase I will add functionality to simplify Ground Vibration Test, or model tuning, by calculating a number of error metric ...

No existing commercial wireless sensor network option meets NASAs current needs for flexibility, size, mass and resilience to extreme environments. The proposed innovation is a MEIS network which combines any number and any type of sensors into a wireless sensor network (WSN), with each of the sensors being motes, or nodes, on the network. The network will be self-healing and self-configuring. Eac ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

The proposed innovation is a membrane bioreactor system to produce a biopolymer from methane gas that is applicable in outer space environments. This new methane fermentation process will expand and advance current gas delivery techniques to create affordable fermentation methods on Earth and beyond. Mango Materials is currently working to scale up and commercialize the production of polyhydroxyal ...