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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Development of a Therapeutic Monoclonal Antibody Against EGFL6, a Mediator of Tumor Growth and Metastasis

    SBC: Tradewind BioScience            Topic: 102

    SUMMARY A diagnosis of ovarian cancer (OvCa) is especially devastating. With 22,240 diagnoses in 2018 and an estimated 14,070 deaths, OvCa has the third-highest mortality rate, leading to the fifth-highest number of cancer deaths among women in the United States. The objective of this research is to validate the anti-tumor function of humanized antibodies with the end goal of identifying and devel ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Multi-stable Compliant-Mechanism-based Mattress for Bedsore Prevention

    SBC: K MEDICAL, LLC            Topic: NINR

    Abstract Pressure ulcers or decubitus ulcers, more commonly known as bedsores are a huge problem affecting 2.5 million patients every year in the US and causes 60,000 deaths every year. Pressures exceeding 32 mm of Hg in the bony prominences in the back of the patient body lead to bedsores. Despite the existing low air loss mattresses, alternating pressure mattresses and the state-of-the-art air f ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: NIMH

    Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations in holographic photostimulation. Specifically, the proposed innovations aim to achieve streaming of high-resolution holograms at up to 10,000 frames per second (fps) to enable closed-loop optogenetic control.Optical imaging and photostimulation have emerged as compl ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment

    SBC: ZYMO RESEARCH CORP.            Topic: NINDS

    PROJECT SUMMARY/ABSTRACT Stroke injury occurs over a long duration through pathologic changes leading to long-term neurologic dysfunction. There is an urgent need of therapeutic strategies that can provide safe and efficacious therapeutic effects to the hypoperfused brain with long-lasting endogenous neuroprotection for prevention of long-term neurologic dysfunction. Sufficient evidence has pointe ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  5. A Transparent Surgical Mask to Improve Patient/Caregiver Communication, Minimize Errors and Increase Patient Satisfaction

    SBC: FaceView Mask, LLC            Topic: NINR

    PROJECT SUMMARY Approximately 4% of people in the US are either deaf or hard of hearing, equating to more than 13 million people. Of these, approximately 12 million people over the age of 5 years have difficulty hearing normal conversation even when using a hearing aid. Hearing difficulties affect all age groups and present significant challenges in daily life. These challenges are particularly ac ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Automated Mental Health Referral System

    SBC: MiResource, Inc.            Topic: 104

    This proposal addresses a significant barrier to obtaining treatment for college-ageyouth with mental disorders. Many college-age youth with impairing mental disordersremain untreated because of concerns about stigma and privacy, inconvenience and wait times, andbecause universities are often unable to service all such students. Also, of critical importance,when referral for treatment is implement ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Multiplexed CRISPR-based immune cell RNA profiling by flow and mass cytometry

    SBC: Dahlia Biosciences, inc.            Topic: NIAID

    Project Summary/Abstract Immune cell profiling is crucial towards understanding key changes in host immune cell subpopulations and functions underlying SARS-CoV-2 viral clearance and immune-mediated pathology. This data will be essential towards the urgent development of COVID-19 diagnostics, therapeutics, and vaccines. Recent publications have showcased the power of scRNA-Seq immune cell profilin ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Mitigation of Ionizing Irradiation-Induced Intestinal Damage by Second-Generation Probiotics LR-IL-22 and LR-IFN-β

    SBC: Chromologic LLC            Topic: R

    Abstract We have developed genetically modified second-generation probiotics for the localized delivery of known mitigators to the GI tract in order to reduce damage and regenerate tissue after exposure to ionizing radiation. Mitigating the effects of ionizing radiation exposure is critical for improving survival in the event of a radiological or nuclear (RAD-NUC) incident, where exposure could le ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Memory-promoting Ad vaccine for long-lived protection against SARS-CoV-2

    SBC: TENDEL THERAPIES INC.            Topic: NIAID

    This grant will establish immunologic proof-of-concept for a second-generation SARS-CoV-2 vaccine providing extraordinarily durable T-cell and antibody responses, which together protect the respiratory mucosa and minimize the risk of antibody-dependent enhancement (ADE). The vaccine platform combines the immunostimulatory power and proven safety of adenovirus-vectored vaccines with novel in- vecto ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Multistage LC-MSn for automated glycan isomer assignment of glycopeptides

    SBC: Protein Metrics Inc.            Topic: 400

    N- and O-linked glycosylation are some of the most common, abundant, and biologically important posttranslational modifications of proteins, yet they are also some of the most difficult to study. The dominant analytical platform for the study of glycosylation is mass spectrometry, yet this platform on its own is incomplete, because it cannot elucidate glycan topology and linkage stereochemistry. T ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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