Award Data

In the setting of altitude-induced hypoxia, operator cognitive capacity degrades and can compromise both individual and team performance. This degradation is linked to falling brain energy (ATP) levels and an increased reliance on anaerobic energy production from glucose. Ketone bodies are the evolutionary alternative substrate to glucose for brain metabolic requirements; previous studies have sho ...

Because of rising demand for human analysts and more efficient processing of increasingly large and challenging amounts of intelligence, human limitations on mental workload, cognitive fatigue, and attentionor task engagement, need to be accurately monitored in real-time in order to provide sensitive detection of impaired cognitive states. It is a challenge to continuously monitor these cognitive ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

On this effort Toyon Research Corp. and The Pennsylvania State University are developing deep learning-based algorithms for object recognition and new class discovery in look-down infrared (IR) imagery. Our approach involves the development of a hybrid classifier that exploits both transfer learning and semi-supervised paradigms in order to maintain good generalization accuracy, especially when li ...

We propose to investigate, in collaboration with MGH Voice Center and Altec, Inc., application of surface electromyography (sEMG) to assessing cognitive workload, strain, and overload. Specifically, sEMG sensors placed on the face and neck will detect emotional/motor responses to workload strain. The proposed effort will build on the substantial sEMG experience of our partner, MGH (including resea ...

The U.S. Navy currently utilizes a number of towed systems from surface ship and submarines for sensing and communication applications. In a number of these cases, a tow cable extends either down from a surface ship or up from a submarine through the upper part of the water column where seawater temperature can be both highly variable vs. depth and dynamic in time and geographic location. Having a ...

BaySpec Inc., in collaboration with Pacific Northwest National Laboratory, proposes to develop a new portable multi-order mass spectrometry system that can sequence peptides derived from biological agents including bacteria, viruses, and toxins. During Phase I stage, a fully functional prototype instrument, based on an innovative design concept, was successfully built and the performance evaluatio ...

Traditional approaches to accelerated fatigue testing rely on heuristic methods with thresholds based mostly on experience and engineering judgment. These methods generally do not apply to the multiaxial dynamic loading situations characteristic of most aerospace applications and often result in uncharacteristic fatigue damage and failure modes during testing. To overcome the limitations of tradit ...

The Department of the Navy has a need for the development of an additive manufacturing (AM) process for key vacuum electronic device components to meet on-demand, flexible, and affordable manufacturing requirements. The goal of this Phase II effort is to develop and validate Electron Beam Melting (EBM) additive manufacturing (AM) technology for the production of vacuum electronic devices meeting t ...

CL-20 is the most powerful conventional explosive known, but its high cost has limited its adoption in a range of potential applications. Par of the challenge in making these materials is the complexity of the reaction used to prepare the polycyclic cage. The complexity of this reaction makes it difficult to have insight into the reaction and to improve it. Additionally, several of the intermediat ...