Award Data

This project will produce a method for constructing treatment plans with a guarantee on the quality of the solution. The plans produced by current techniques can fall short of the optimum or needlessly fail to satisfy constraints. As a result, the search for an improved solution is open-ended, exhausting hospital resources and manpower, and providing no assurance to patient or physician that a b ...

DESCRIPTION: (Adapted from Applicant's Abstract) Malaria is a disease which affects more than 300 million people each year and is fatal for 1.5 million. The overall objective of this STTR Phase I project is to produce a cGMP malaria vaccine consisting of the 42 kDa C-terminal polypeptide of P. falciparum merozoite surface protein-1 (MSP1.42) to be formulated with ...

DESCRIPTION (Applicant's abstract): Psoriasis is a common, inflammatory disease of the skin characterized by hyper-proliferation of keratinocytes. A variety of antipsoriatic therapies are available, however, due to problems with side effects and variability in clinical response, intense clinical and commercial interest remains in the development of new treatments. Thiaz ...

DESCRIPTION (Applicant's abstract): Psoriasis is a common, inflammatory disease of the skin characterized by hyper-proliferation of keratinocytes. A variety of antipsoriatic therapies are available, however, due to problems with side effects and variability in clinical response, intense clinical and commercial interest remains in the development of new treatments. Thiaz ...

DESCRIPTION (Verbatim from Applicant): We will develop biomimetic materials for repair and orthoplasty of the orbit and surrounding bony structures. These scaffolds will incorporate a cell binding peptide related to collagen which will allow them to serve as collagen-like anchorages for cells. These Collagen Surrogate Matrices (CSM) will facilitate haptotactic migrati ...

DESCRIPTION: (Adapted from the Applicant's Abstract) Traumatic spinal cord injury (SCI) leads to permanent loss of motor function and control of function below the level of the injury. A significant portion of the loss is due to secondary factors rather than the initial trauma. These factors include increased extracellular concentrations of glutamate which ha ...

DESCRIPTION (provided by applicant): Cocaine abuse remains a grave concern for the American, and increasingly the world, population. As no current therapeutic agents are available to assist cocaine addicts in achieving and maintaining abstinence it is important that new pharmacotherapies be developed. One important question not usually addressed in the development ...

DESCRIPTION (provided by applicant): Identifying amino acid residues of a protein that form the binding site for a drug, or that are present at the interface in a protein-protein complex are difficult to identify from the crystal structures of the individual partner proteins. Carta Proteomics is committed to the premise that monitoring isotope exchange in ...

DESCRIPTION (provided by applicant): The current paradigm in therapeutic nuclear medicine is to optimize receptor binding molecules and then add on a moiety capable of carrying a radioisotope. This "afterthought" modification process results in suboptimum performance for such agents when dealing with molecules smaller than monoclo ...

DESCRIPTION (provided by applicant): The most commonly used statistical methods for the design and analysis of cancer clinical trials today rely heavily on the idea of proportional hazards or its generalizations; i.e., that the important differences between treatments are reflected in the differences between failure rates. Implicit in the use of these methods is the assumptio ...