Award Data

There are several current and imminent orthotic and prosthetic (O&P) fitting scenarios that would greatly benefit from the ability to wirelessly collect and transmit physiological information from the user. Both upper- and lower- limb O&P fittings that: 1) use osseointegration, 2) have cable management issues, and 3) could benefit from physiological information from locations proximal to the prost ...

Rodents serve as models for the human brain and behavior, and their calls give researchers a window into their mood. Unfortunately, rodent calls are ultrasonic, so a researcher must record a test and then play the audio back at a slower speed to manually categorize and count calls. Software does exist to accomplish this task, but it does not have the ease of use or accuracy that researchers want. ...

Accurate assessment of burn depth and surface area are important to clinical decision-making regarding treatment. Initial assessment determines fluid requirements and transportation decisions to distant-care facilities. The clinician must determine if the wound will heal itself or whether excision and grafting are necessary for optimal wound healing. The standard of care remains visual inspection ...

It is generally recognized that the human body transmits electro-magnetic fields (EMF). The Phase I program demonstrated a practical solution to detect these emissions. The technology was shown to be compatible for integration into wearable textiles. The Phase 2 program will focus on demonstrating the capability of discriminating between healthy and injury related EMF emissions such that it can be ...

Airway compromise is the third leading cause of potentially preventable death on the battlefield. Current evaluation techniques of the airways associated with smoke inhalation injury are highly subjective and lack the sensitivity required of an accurate diagnostic and assessment tool. The problem of detection is further compounded by the late onset of symptoms that in many cases do not present unt ...

GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

Triton Systems, Inc. proposes to develop a piezo-textile that can capture underwater explosion pressure wave patterns to ultimately establish and monitor for injury risk severity. We propose to use a state-of-the-art piezo-textile to which we will apply our own proprietary treatments.We will assess our textiles pressure detection performance and durability against a non-textile piezoelectric array ...