Award Data

DESCRIPTIONprovided by applicantPeople in recovery from serious mental illness are often excluded from making decisions about their own mental health carefrequently resulting in poor alliances with their care providersWhile the Patient Protection and Affordable Care Act addresses this issue by requiring programs to be person centered and recovery orientedproviders often struggle to identify concre ...

DESCRIPTIONprovided by applicantTherapeutic Reversal of Endothelial Dysfunction in Atherogenesis Cardiovascular disease is the leading cause of morbidity and mortality in the worldIn particularatherosclerosis is a life threatening disease strongly associated with risk factors such as elevated cholesterol levelshigh blood pressure and diabetesThere are effective commercially available therapeutics ...

DESCRIPTIONprovided by applicantThe goal of the project is to develop a therapeutic against vancomycin resistant enterococcusVREThese infections are a serious health concern because antibiotic resistance has gotten to the point where there are few or no effective treatment options availableFor the enterococciresistance is inherently linked to toleranceth ability of the pathogen to survive in the p ...

DESCRIPTION provided by applicant Obesity has reached epidemic proportions in the U S and plays a major role in the development of type diabetes dyslipidemia and cardiovascular disease There remains a very significant need for better non surgical treatments While most weight loss agents rely on suppressing appetite to reduce caloric intake strategies that can safely enhance energy expe ...

DESCRIPTION provided by applicant Alzheimerandapos s disease AD is one of the most significant public health problems of the st century with the number of patients in the US estimated to grow from million to million by and an annual cost of care projected to reach $ trillion Current treatments for AD have limited effect for a short duration and only serve to alleviate sympto ...

DESCRIPTION provided by applicant Recording all the neural activity in a D volume with millisecond timescale precision is a key goal of the BRAIN initiative Recently in a collaborative project with the Vaziri lab IMP Vienna we adapted the strategy of lightfield microscopy for D volumetric imaging of fluorescent neural calcium responses Prevedel This technology enables computatio ...

PROJECT SUMMARY Reverse phase protein arrayRPPAhas emerged as a promising antibody based highly quantitative proteomic technology suitable for profiling proteins in hundreds to thousands of patient samplesThe throughputsensitivityand cost effectiveness of RPPAtogether with its ability to deal with minuscule sample amountshave propelled applications of the technology in basicpreclinical and clinica ...

DESCRIPTION provided by applicant Atopic dermatitis AD or severe eczema is a very common life long skin disease with of adults in the US requiring systemic therapy Clinical manifestations of AD include multiple inflamed lesions erosions accompanied by lichenification thick leathery skin fibrotic papules and severely dry skin with increased susceptibility to infection A major uncont ...

PROJECT SUMMARY ABSTRACT Diabetic foot ulceration has a complicated biomechanical pathology that involves not only plantar pressure but also shear stresses and physical activity among other factors A number of pressure ulcer studies have also demonstrated that warmer tissue is more vulnerable to breakdown when compared to cooler tissue Diabetic ulceration and related amputations impairs quality ...

Abstract of administrative supplement The original objective was to use a novel plant biotechnologytarget directed evolutionto produce novel inhibitors of the human dopamine transporterDATas leads for medications for alcohol use disorderThis approach evolves plant biosynthesis toward a specific target by a combination of mutagenesis and selectionLobelia cardinalis was used as the plant species bec ...