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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Ultrahigh Performance Non-Denaturing Protein Chromatography Columns

    SBC: BIOVIDRIA, INC.            Topic: 400

    PROJECT SUMMARY The proposed product is an analytical scale UHPLC column for separating protein drugs in native form with the Phase I proposal focused on anion exchange chromatography as the separation mechanism The bonded phase is made of polymer chains in this case bearing weak anion exchange groups The study will be expanded to cation exchange and hydrophobic interaction chromatography in ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Therapeutic targeting of Nox2 and Nox4 in Duchenne Muscular Dystrophy

    SBC: Fibronox            Topic: NHLBI

    ABSTRACT: Duchenne muscular dystrophy (DMD) caused by a genetic mutation that prevents the production of dystrophin, a protein that muscles need to work properly. DMD patients exhibit progressive muscle weakness occurs in both skeletal and cardiac muscle. Cardiac fibrosis is ultimately the leading cause of their premature death. There is no cure for DMD, thus it remains an unmet medical need. Any ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. The MICELI Aggregometer: a Point-of-Care Platelet Function Analyzer

    SBC: PLAKDX, LLC            Topic: NHLBI

    PROJECT SUMMARY: While platelets are vital blood cells to maintain vascular integrity and foster tissue repair, unfortunately they may become “inappropriately” activated in a wide range of disease states. To reduce this activation risk anti- thrombotic drugs are routinely prescribed to an ever increasing variety of patients, in fact being leading agents prescribed by physicians today. While th ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Targeting the neuropilin-1 receptor (NRP-1)/VEGF-A axis for neuropathic pain

    SBC: Regulonix            Topic: 107

    ABSTRACT Revisions noted in blue font First reported in December of 2019, coronavirus disease (COVID-19) has taken the world by storm, exacting a heavy toll not only in terms of the number of deaths (~1,700,000) it has caused worldwide but also its decimation of world economies (~$8.8 trillion). Because infection with SARS-CoV-2, the causative agent of COVD-19, can be spread by asymptomatic, presy ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Targeting Necroptosis for Neurodegenerative Disease Therapy

    SBC: REGENERIX LLC            Topic: NIA

    PROJECT SUMMARY/ABSTRACT The long-term objective of the project is to develop therapeutics for Alzheimer’s that inhibit a unique method of cell death known as necroptosis. This cell death pathway has been known to be upregulated in neurodegenerative diseases, highlighting the need to find therapeutics that target the proteins involved. Several kinases are known to be important regulators that in ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Target Identification for Novel Small Molecule Therapeutic for Alzheimer's disease

    SBC: CoPlex Therapeutics, LLC            Topic: NIA

    ABSTRACT Traditional approaches to drug development for Alzheimer s disease are becoming increasingly expensive and in many cases disappointingly unsuccessful Based on preliminary in vitro and in vivo studies we have identified a novel small molecule methyl dimethyl oxo dihydrobenzo c naphthyridine carboxylate UK that significantly decreases A production and pro in ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Targeted and Non-targeted Microbubbles for Pediatric Applications

    SBC: NUVOX PHARMA, L.L.C.            Topic: NICHD

    Project Summary Staphylococcus is the most common cause of community and hospital acquired infective endocarditis worldwide Staphylococcal S aureus endocarditis is a serious health problem in children and adults that carries high morbidity and mortality The incidence of this disease is increasing due to healthcare advances with widespread use ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Stress forces huESC differentiation; confirmation as an accurate DevTox HTS

    SBC: REPRODUCTIVE STRESS MEASUREMENT MECHANISMS & MANAGEMENT CORP            Topic: R

    EXECUTIVE SUMMARY - huESC HTS2 - human Toxic stress effects in 1st trimester pregnancy leads to $10s of billions of US health care costs/year and is a significant part of the $2.5-4B/year US Developmental and Reproductive Technology (DART industry. Current DART techniques use slow, expensive pregnant rodent tests, or tests of embryonic stem cells (ESCs) that are cultured to lose “stemness” and ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Single-Molecule Analyte Detection by Molecular Motor-driven Nanodevices

    SBC: Attometrics            Topic: NIGMS

    DESCRIPTION provided by applicant There is an urgent need for a platform technology that can monitor changes in metabolite and protein biomarkers below current detection limits because in many cases the disease has progressed to an advanced state by the time the abundance of the biomarker has become measurable Our molecular motor powered nanodevice linked immunosorbent assay MONA LISA is ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. RememberStuff: a dyadic-focused technology to support persons with Alzheimer's disease in the community

    SBC: EPERTURE LLC            Topic: NIA

    Project Abstract An estimated 5.7 million Americans have Alzheimer’s disease or a related dementia (ADRD) and one in ten people age 65 or older show symptoms of Alzheimer’s disease. As ADRD progresses so does the level of dependency on others. As the disease progresses, higher levels of dependence in people with Alzheimer’s disease are associated with significantly increased burden and costs ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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