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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Modified Grids for Biological Sample Capture to Accelerate CryoEM Structure Eluci

    SBC: Pandion Laboratories LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Cryo-electron microscopy (cryoEM), in the form of single particle reconstruction (SPR) and cryo-electron tomography (cryoET) analysis are rapidly growing methods for determining the three-dimensional molecular structures of biological samples. This burgeoning interest stems from the fact that the size or complexity of the biological objects that can be analyzed ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  2. Magnetic Drive Mechanism for VF Doppler Smart Sensor

    SBC: ARBOR ULTRASOUND TECHNOLOGIES, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Prior to dialysis vascular access failure (thrombosis), blood flow decreases from a baseline value to zero over some unknown time period. While the natural history and variation of flow prior to access failure is poorlyunderstood, it is known that customary monthly access flow monitoring is not frequent enough in many clinical settings for adequate prediction a ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Target Identification for Novel Small Molecule Therapeutic for Alzheimer's disease

    SBC: CoPlex Therapeutics, LLC            Topic: NIA

    ABSTRACT Traditional approaches to drug development for Alzheimer s disease are becoming increasingly expensive and in many cases disappointingly unsuccessful Based on preliminary in vitro and in vivo studies we have identified a novel small molecule methyl dimethyl oxo dihydrobenzo c naphthyridine carboxylate UK that significantly decreases A production and pro in ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Fully Metallic Self-Fragmenting Structural Reactive Materials Using Composites and Alloys Comprised of Aluminum, Lithium, and Magnesium

    SBC: Adranos Energetics LLC            Topic: DTRA16A002

    While aluminum casing materials provide some enhanced performance and thermal loading to explosive ordinance, their overall effectiveness is highly limited by incomplete combustion and long residence times. In order to reduce these problems, the casing material must be designed to facilitate rapid fragmentation through either specialized casing geometries or greatly refined initial particle sizes. ...

    STTR Phase I 2016 Department of DefenseDefense Threat Reduction Agency
  5. General Purpose Radiation Detector Front End and Digital Processor

    SBC: H3D INC            Topic: DTRA20B002

    This project aims to create a general-purpose readout architecture that will allow the rapid deployment of next generation detection systems. The system will be based on the development of a programmable general-purpose integrated circuit (GPIC) that has the front-end electronics required to read out signals from a variety of radiation detectors, especially next generation scintillators and semico ...

    STTR Phase I 2021 Department of DefenseDefense Threat Reduction Agency
  6. Development of Percutaneous DLC for Total Cavo-pulmonary Assistance

    SBC: W-Z BIOTECH LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The Fontan procedure is currently standard care for patients with complex single ventricle congenital heart defects. The Fontan procedure involves the creation of a cavopulmonary (CP) shunt connecting the inferior and superior vena cava (IVC and SVC) directly to the right pulmonary artery (RPA), diverting total venous return from the IVC/SVC directly to the PA ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  7. Novel therapies for inherited muscle diseases

    SBC: Medosome Biotec, LLC            Topic: NIAMS

    DESCRIPTION provided by applicant The pursuit of novel therapies informed by the astounding advances in biomedical science of the past half century has been fruitful for many disorders However inherited muscle diseases such as muscular dystrophy remain stubbornly resistant to sophisticated molecular approaches to therapy A few therapies are finally edging towards approval but it has become ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Personalized dosing of dichloroacetate for the treatment of rare and common diseases

    SBC: Medosome Biotec, LLC            Topic: NICHD

    ABSTRACT SUMMARY Pyruvate dehydrogenase complex PDC deficiency PDCD is a rare disease of mitochondrial energy failure in which the life of expectancy of affected children is severely truncated Treatment of PDCD remains a serious unmet challenge There has never been a controlled trial of any intervention for PDCD thus there is no proven therapy for affected patients Dichloroacetate DCA ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Developing a novel adjuvant system for therapeutic vaccines against lung cancer

    SBC: FasCure Therapeutics LLC            Topic: 102

    DESCRIPTION provided by applicant Therapeutics is focused on the development of adjuvant systems with desired immune activities for targeted indications The Companyandapos s immune stimulatory adjuvant platform builds on combinatorial use of immune agonists with distinct immune targets and mechanisms of action for the generation of therapeutic immune responses Critical to this platform techno ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Cryopreservation and Cloning of Somatic Cells to Preserve Zebrafish Germplasm

    SBC: FreezeBack, LLC            Topic: OD

    DESCRIPTION provided by applicant Freezing whole zebrafish embryos in order to later recover live fish is not currently possible Researchers seeking to preserve zebrafish genetic lines are presently limited to the options of storing frozen sperm in sperm banks or maintaining the fish alive These limitations increase costs and hinder the efficient dissemination of superior wild type and mutan ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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