Award Data

ABSTRACT: High power and low insertion loss WDM components will be developed. In manufacturing WDM components, solid core fibers in both polarization insensitive and polarization maintaining, will be pursued, along with photonics crystal fiber components. A range of fiber sizes and device specifications will be developed and commercially offered by Q-Peak. The component that we propose to develo ...

ABSTRACT: Aurora will demonstrate on our automated fiber placement (AFP) machine that we are able to lay up composite panels that contain sacrificial fibers that can be thermally decomposed to create a microvascular network of small cavities that allow the panel to act as a heat exchanger. The AFP machine is capable of producing composite parts from mold tools as large as 9"high by 18"wide by 56 ...

ABSTRACT: In ISR applications, multiple sensors can be employed to achieve more accurate parameters of interest on targets, improving discrimination and detection. But, the proliferation of sensor systems has created a large volume of multi-sensor data across a number of physical spectra. These resulting measurements can be so disparate that traditional aggregation methods perform poorly given h ...

ABSTRACT: Intelligence analysts need to process large amounts of text information to form an understanding of a topic of interest. The sheer amount of information can be overwhelming, so automated text analytics that assist with filtering, information extraction, and document understanding, can be highly beneficial. Deep natural language processing (NLP) applications require both structural knowl ...

ABSTRACT: Information is a national asset that must be protected. To make effective use of this asset, information sharing is critical between government agencies, with foreign government partners, and with the private sector. At the same time, in practice, balancing information sharing and information protection can be difficult. Tools are needed to address many challenges, including managing ...

ABSTRACT: Close integration of photonic devices with silicon complementary metal-oxide semiconductor (CMOS) electronics can yield significant performance improvements in many applications. The recent development of novel integrated structures in silicon including waveguides, resonators, and photodetectors will enable dramatic reductions in size, weight, and power for components implementing compl ...

DESCRIPTION (provided by applicant): The broad and long-term objective of this project is to amplify the effectiveness of vaccines without the use of chemical or biological adjuvants. We will address this objective by demonstrating the feasibility for small laser- based devices to enhance responses to intradermal vaccination. A number of investigators have shown that a promising new way to make va ...

DESCRIPTION (provided by applicant): We invented an innovative protein induced Pluripotent Stem Cells (piPSCs) technology that generates piPSCs from normal fibroblast and cancer cells within 1-week with 90 4% conversion efficiency. Such high conversion efficiency enables us to pioneer an in situ cell reprogramming technology within the cancers of cancer-bearing animals. Instead of generating iPSCs ...

Project Abstract Active surveillance (AS) is becoming more accepted as a reasonable treatment option for men with low-risk prostate cancer (i.e. Gleason score 6, clinical stage T2a, PSA lt 10). Many AS protocols at major institutions call for a prostate saturation biopsy after initial diagnosis to confirm that the patient has no areas of higher-risk prostate cancer. For most patients who underwent ...

DESCRIPTION (provided by applicant): Cisplatin is a cornerstone therapy for a number of cancers including testicular, bladder, ovarian and lung. It is also used to treat cancers in children. In all cases there is a high incidence of acute kidney injury (AKI) that can also lead to later stage kidney damage. This risk limits its use. We have found in pilot studies that renalase, or peptide fragment ...