Award Data

Current strategies for the treatment of osteochondral injuries are ineffective and are associated with significant side effects. Microfracture techniques have demonstrated limited efficacy over long periods of time and are less effective for larger osteochondral defects. Osteochondral autograft transplants require harvesting from a donor site, which can lead to donor site morbidity. Further, while ...

Parabon NanoLabs (PNL) has designed and demonstrated the feasibility for a new hybrid vaccine nanostructure that is based upon a DNA origami that can include protein antigens or epitopes, immune stimulators, cell targeting ligands and a transfection plasmid.This approach offers the opportunity for crafting molecularly defined vaccine nanostructures that stimulate a specific primary response that i ...

The Aerial Reconfigurable Embedded System (ARES)allowsalarge payload to beindependently configured to meet themission needs. This PhaseIIeffort will develop amission payload for use on the DARPA ARES Technology Demonstrator fora Casualty Evacuation (CASEVAC) Module. Under thiseffort the PiAC team willevaluatetheexisting pod structureto assess theintegration ofasinglelitter,medical crew personnelan ...

Vascular trauma is the leading cause of death in military environments and hemorrhage is the major preventable cause of mortality among trauma patients. Recent experience from Iraq and Afghanistan has demonstrated improved 24-h and 30-day survival in combat casualties requiring early massive transfusion. Unlike plasma and erythrocytes, which can be cold stored for longer time periods, platelets ca ...

Leveragingour expertise in electro-opto-mechanical device development and system integration (hardware and software) and the Phase-I achievement, Hitron Technologies Inc. (HTI) proposes to develop an autonomous solution tentatively named Tick Collection

During combat a soldier may incur treatable injuries beyond the expertise of the combat medic. Addressing this by deploying more knowledgeable Medical Officers per-squad could be life-saving and significantly improve battlefield injury recovery. However, limited resources often prevent deployment of such expertise per-squad. During our Phase I RACC development, Neya Systems has successfully demons ...

We have developed a device to control intracranial hemorrhage without a craniotomy.The device stops hemorrhage transcranially.This has been demonstrated in pig cadavers.We have developed a functional prototype and intend to improve and test the device on human cadavers and in vivo in pigs.By the end of the proposed work, we expect to be prepared to submit IDE paperwork with the FDA and engage inve ...

The objective of this Phase II project is to translate the proof of concept prototype developed in Phase I towards practical implementation. The focus will be on transtibial prosthetic legs. The Phase I design will be improved for bio-mechanical functionality, reliability and cost effectiveness. Full size and full load scale products will be experimentally tested and evaluated with transtibial amp ...

Complete human anatomy avatars have a broad role in advanced training environments, performance-related physiological modeling, and simulations for the purpose of designing protective armor. The overall goal of this project is to design and develop computer software and data structures for adding articulated joints and natural motions to USARIEMs static finite element avatars and to create a graph ...

Current thermal and chemical burn care practices such as debridement and physical therapy produce intense pain for patients. The management of this intense pain relies almost exclusively on systemically administered opioids or other pain medications, which are known to produce side effects as serious as opioid dependence.The need to reduce opioid use can be met by delivering the known effective op ...