Award Data

This Small Business Technology Transfer project will develop a mathematical framework and enabling technologies for context-aware target classification and selection for missile defense systems in the presence of counter-measures and clutter in realistic scenarios. Based on statistical relationship learning (SRL) methodology, the proposed framework can reason simultaneously about multiple entries ...

In this research effort, GTD Unlimited will design tools for efficiently specifying, representing, and analyzing the interactions between control systems in System of Systems (SoS). Our approach will be to model the problem as an uncertain system and analyze the resulting models using control methods. Control methods can be related back to the standard Nyquist criterion for stability, ensuring t ...

The experimental validation of the DoDs weapon systems is at the cornerstone of national security considerations. The structural requirements for the targets utilized impose a severe cost and lead time burden due to the limitations imposed by the traditional manufacturing processes currently used. Novel manufacturing methods for metal alloys have been established in the past years, but they have y ...

The Missile Defense Agency (MDA) has multiple system platforms to defeat an Intercontinental Ballistic Missile (ICBM).The MDAs solution for defeating a midcourse threat is the Ground-Based Midcourse Interceptor (GMI).The GMI is comprised of the Orbital Boost Vehicle (OBV) and an Exoatmospheric Kill Vehicle (EKV), developed by Orbital ATK and Raytheon respectively.The OBV carries the EKV to the ICB ...

Control Theory tools and processes for analyzing the interactions of complex System of Systems (SoS) are lacking, specifically when sub-systems are independently designed and/or higher levels of SoS controls are applied. Integrating these sub-systems into the SoS, can result in dynamic interactions between these sub-systems and the SoS controls resulting in unexpectedly large deviations between ex ...

The focus of this STTR phase I component is on proof-of-concept studies demonstrating applicability of technical approaches for identificationof circulatory diagnostic markers for infectious disease. Therefore, the primary objective of this project is to determine feasibility of one suchtechnical approach called Proteomics-based Expression Library Screening (PELS), for identification of pathogen-d ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

In a pandemic or exposure to weaponized Marburg virus the morbidity, mortality and social unrest that will ensue before vaccines orMilitary operating on foreign soil as well as to the population of the US Homeland. Practically all threat agents of biological origin (except forcertain non-proteinaceous toxins, typically produced by marine organisms and fungi) have their structure and vital function ...

Marburg virus (MARV) is a filamentous enveloped non-segmented negative sense RNA virus. This viruse is considered to be extremelydangerous with case fatality rates as high as 88-90%. Extensive efforts have gone towards effective vaccines for MARV prevention, however,none have been successfully established as licensed vaccines. Glycoprotein (GP) is the only surface protein of MARV. There are substa ...

The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust molecula