Award Data

Enzalutamide resistance is a major obstacle in the treatment of metastatic castration resistant prostate cancer mCRPC Recently we developed a small molecule lead compound BKM and demonstrated its potent activity against bone metastatic prostate cancer cells In this Phase I STTR application we hypothesize that BKM is a novel targeted therapy to overcome enzalutamide resistance and eff ...

Abstract Liver fibrosis cirrhosis is one of the most common outcomes of chronic liver disease Chronic liver disease is assessed by progressive fibrosis caused by repeated injury due to metabolic dysfunction alcohol abuse viral hepatitis or autoimmune disease If it is left unchecked liver fibrosis will progress to cirrhosis an advanced stage of the disease estimated to affect of the wor ...

Project Summary Notch is a cell surface protein that has diverse roles in human biology at all stages of life Notch is modified by a number of sugar structures including a number that are termed O fucose Alteration of the pattern of O fucose structures found on Notch has significant effects on Notch function which in turn has been linked to both developmental and adult pathologies includ ...

DESCRIPTION provided by applicant Insulin resistance IR also known as metabolic syndrome is tied to obesity and is associated with numerous modern health problems including the growing problems of type diabetes and cardiovascular disease The growing health economic and social burdens of these conditions calls for the need to develop drug treatments for IR We know from multiple lines of ...

DESCRIPTION provided by applicant Problem Lower gastrointestinal bleeding is a significant medical problem in the United States accounting for more than hospital admissions and tens of billions of dollars of healthcare spending annually It is common for bleeding from a single site to stop and restart multiple times The three modalities now used to diagnose and locate gastrointestina ...

Sexual violence SV experienced by women on college campuses is a serious public health problem that has garnered a national response Campus climate surveys show that approximately one in five college women experience sexual violence Federal regulations now mandate implementation of educational prevention programs for new students of institutions of higher education IHEs Best practices for s ...

Project Summary Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite technological efforts to a ...

The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust molecula

Establish a radiation-aware analysis capability in a commercial EDA design flow that will enable first-pass success in radiation-hardened by design (RHBD) for DoD ASICs in much the same way that existing EDA design suites ensure first pass functionality and performance success of complex ASICs destined for commercial applications. Layout-aware, calibrated single-event radiation models that captur ...