Award Data

In the setting of altitude-induced hypoxia, operator cognitive capacity degrades and can compromise both individual and team performance. This degradation is linked to falling brain energy (ATP) levels and an increased reliance on anaerobic energy production from glucose. Ketone bodies are the evolutionary alternative substrate to glucose for brain metabolic requirements; previous studies have sho ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

The objective of this proposal is to develop instrumentation and algorithms for acquiring facial features for facial recognition in low- and no-light conditions.We will use cross-spectrum matching by exploiting infrared polarimetric imagery which tends to show features that match more closely visible imagery than conventional infrared.In addition to thermal infrared, we will also test subjects in ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

This proposal is to develop a Handoff Training for Combat Casualty Care (HTC3) Framework.Training is the crux of the handoff problem today. Patient handoffs are a crucial part of casualty care, both in military and civilian environments; and today handoffs are being performed in less than optimal fashion, with ineffective communications accounting for 80% of the handoff errors. Our new HTC3 Framew ...

Biomimetic Slope Adaptive Foot-Ankle Prosthesis This project will develop an innovative mechanical/hydraulic foot-ankle system that will help lower extremity prosthesis wearers to walk or run in a wider range of environments with close to normal walking biomechanics. The proposed system will have a unique combination of features, all mechanically implemented without electronics or external powe ...

Makel Engineering, Inc. and Sandia National Laboratories propose to demonstrate an advanced multi-modal sensor system suitable for in-situ analysis of exhaled VOCs for pilots, divers and field patients. Our proposed system will combine a micro-gas chromatograph (GC) and miniature ion mobility spectrometer (IMS) for detection of trace amounts of exhaled breath VOCs with miniature solid state sensor ...

BaySpec Inc., in collaboration with Pacific Northwest National Laboratory, proposes to develop an innovative orthogonal sensor systemthat would be able to detect, identify and quantify the inorganic components of breathing mixes, (i.e., nitrogen, oxygen, carbon dioxide, argon, helium, and water vapor), as well as individual detectable VOCs within the exhaled breath in real-time. The Phase I resear ...

There is a lack of quantitative tools to accurately map tissue viability in a rapid and quantitative manner so a surgeon can properly excise tissue prior to grafting. Spatial Frequency Domain Imaging (SFDI) is an optical method that has been shown to be a reliable method for physiology assessment - particularly for burn depth. SFDI measures of tissue structure (scattering) and function (hemoglobi ...