Award Data

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens, whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial and alphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable an ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...

Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is to help find natural gas leaks to improve public safety and reduce natural gas rates. Natural gas leaks have led to fires and explosions that have injured hundreds of people, including some fatalities, and resulted in over $2 B in costs. By finding leaks before they become dangerous, improved detec ...

During altitude-induced hypoxia, operator cognitive and physical capacity degrades, compromising individual and team performance. Cognitive degradation is linked to falling brain energy levels, increased reliance on anaerobic energy production and lactate accumulation. Ketones are the evolutionary alternative substrate to glucose for brain metabolic requirements; previous studies demonstrated that ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase II project will enable collaboration with sensitive data. This will increase the ability of companies and institutions in sensitive domains, including biomedicine, to apply existing machine learning models and increase their ability to train new, more sophisticated models, thereby improving insights for ...

The broader/commercial impact of this Small Business Technology Transfer (STTR) Phase I project is to advance development of an innovation in lubricant viscosity sensing to enable continuous oil condition monitoring. There are 285 million vehicles, aircrafts and vessels in the US, and more than one-half of the lubricant changes based on mileage and time are estimated to be premature and unnecessar ...

The broader impact of this Small Business Technology Transfer (STTR) Phase I project will be an affordable, portable breath analysis device to detect marijuana intoxication. First responders, law enforcement, medical professionals, cannabis users, and the general public will benefit from an analytical tool that allows fast and accurate screenings of cannabis impairment. An estimated 37,000 people ...

This broader impact/commercial potential of this STTR Phase I project is to address certain medical procedures, such as percutaneous nephrolithotomy (PCNL). Currently, one in 11 people develop kidney stones by the age of 70, with a lifetime recurrence rate of 60-80%. PCNL, which involves removal of kidney stones through a surgical channel into the kidney, is the preferred method for stones less th ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to open new orbital flight regimes to CubeSat and microsatellite vehicles. Vehicles of these size classes are currently constrained by the lack of suitable propulsion options or additional regulatory burdens that most propulsion systems levy on rideshare vehicles. Most small satellites in L ...